Review
doi: 10.1038/nrn3786.
Epub 2014 Aug 6.
Integrating the active process of hair cells with cochlear function
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- PMID: 25096182
- DOI: 10.1038/nrn3786
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Review
Integrating the active process of hair cells with cochlear function
Nat Rev Neurosci.
2014 Sep.
Abstract
Uniquely among human senses, hearing is not simply a passive response to stimulation. Our auditory system is instead enhanced by an active process in cochlear hair cells that amplifies acoustic signals several hundred-fold, sharpens frequency selectivity and broadens the ear's dynamic range. Active motility of the mechanoreceptive hair bundles underlies the active process in amphibians and some reptiles; in mammals, this mechanism operates in conjunction with prestin-based somatic motility. Both individual hair bundles and the cochlea as a whole operate near a dynamical instability, the Hopf bifurcation, which accounts for the cardinal features of the active process.
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