Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1989 Oct;16(10):3386-91.

[Mechanisms of macrophage activation and macrophage-mediated tumoricidal activity]

[Article in Japanese]
C Kiyotaki  1
Affiliations
  • PMID: 2508564
Review

[Mechanisms of macrophage activation and macrophage-mediated tumoricidal activity]

[Article in Japanese]
C Kiyotaki. Gan To Kagaku Ryoho. 1989 Oct.

Abstract

Macrophages exert important roles in the host defense mechanism, such as antigen presentation and destructions of tumor cells. Analysis of macrophage functions as effector cells in the tumor cell destruction has been carried out mainly from two aspects. One is the macrophage activation, during which macrophages are sequentially activated from resting cells to fully activated cells with capability to destroy tumor cells. The other is analysis of active moieties which mediate macrophage tumoricidal activity. The recombinant cytokines become available, and IFN-gamma has been found to be a major constituent of macrophage activating factor. It has been also reported that TNF, -IL-4, GM-CSF or IL-2 has MAF activity. The precise mechanism of signal transduction of IFN gamma will be defined by the recent progress on IFN gamma receptor purification and gene cloning for IFN gamma receptor as well as on the analysis of IFN gamma-inducible genes. As the mechanism of macrophage-mediated tumoricidal activity, two pathways, TNF-dependent and arginine-dependent ones, have been proposed.

PubMed Disclaimer

Similar articles

See all similar articles

MeSH terms

LinkOut - more resources