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Review
. 2014 Dec;1846(2):277-84.
doi: 10.1016/j.bbcan.2014.07.006. Epub 2014 Jul 25.

The unfolded protein response as a target for cancer therapy

Anika Nagelkerke  1 , Johan Bussink  2 , Fred C G J Sweep  3 , Paul N Span  4
Affiliations
Review

The unfolded protein response as a target for cancer therapy

Anika Nagelkerke et al. Biochim Biophys Acta. 2014 Dec.

Abstract

Various physiological and pathological conditions generate an accumulation of misfolded proteins in the endoplasmic reticulum (ER). This results in ER stress followed by a cellular response to cope with this stress and restore homeostasis: the unfolded protein response (UPR). Overall, the UPR leads to general translational arrest and the induction of specific factors to ensure cell survival or to mediate cell death if the stress is too severe. In multiple cancers, components of the UPR are overexpressed, indicating increased dependence on the UPR. In addition, the UPR can confer resistance to anti-cancer treatment. Therefore, modification of the UPR should be explored for its anti-cancer properties. This review discusses factors associated with the UPR that represent potential therapeutic targets.

Keywords: Autophagy; Cancer; Endoplasmic reticulum stress; Therapy; Unfolded protein response.

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