doi: 10.1186/gm561.
eCollection 2014.
Why epistasis is important for tackling complex human disease genetics
Affiliations
- PMID: 25031624
- PMCID: PMC4062066
- DOI: 10.1186/gm561
Item in Clipboard
Why epistasis is important for tackling complex human disease genetics
Genome Med.
.
Erratum in
-
Erratum to: Why epistasis is important for tackling complex human disease genetics.Genome Med. 2015 Sep 7;7(1):85. doi: 10.1186/s13073-015-0205-8. Genome Med. 2015. PMID: 26343148 Free PMC article. No abstract available.
Abstract
Epistasis has been dismissed by some as having little role in the genetic architecture of complex human disease. The authors argue that this view is the result of a misconception and explain why exploring epistasis is likely to be crucial to understanding and predicting complex disease.
Similar articles
-
Erratum to: Why epistasis is important for tackling complex human disease genetics.Genome Med. 2015 Sep 7;7(1):85. doi: 10.1186/s13073-015-0205-8. Genome Med. 2015. PMID: 26343148 Free PMC article. No abstract available.
-
Genotypic Context and Epistasis in Individuals and Populations.Cell. 2016 Jul 14;166(2):279-287. doi: 10.1016/j.cell.2016.06.047. Cell. 2016. PMID: 27419868 Free PMC article. Review.
-
Epistasis and its implications for personal genetics.Am J Hum Genet. 2009 Sep;85(3):309-20. doi: 10.1016/j.ajhg.2009.08.006. Am J Hum Genet. 2009. PMID: 19733727 Free PMC article. Review.
-
A model and test for coordinated polygenic epistasis in complex traits.Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e1922305118. doi: 10.1073/pnas.1922305118. Proc Natl Acad Sci U S A. 2021. PMID: 33833052 Free PMC article.
-
Why epistasis is important for selection and adaptation.Evolution. 2013 Dec;67(12):3501-11. doi: 10.1111/evo.12214. Epub 2013 Aug 12. Evolution. 2013. PMID: 24299403
Cited by
-
A rapid epistatic mixed-model association analysis by linear retransformations of genomic estimated values.Bioinformatics. 2018 Jun 1;34(11):1817-1825. doi: 10.1093/bioinformatics/bty017. Bioinformatics. 2018. PMID: 29342229 Free PMC article.
-
A survey about methods dedicated to epistasis detection.Front Genet. 2015 Sep 10;6:285. doi: 10.3389/fgene.2015.00285. eCollection 2015. Front Genet. 2015. PMID: 26442103 Free PMC article. Review.
-
Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments.Philos Trans R Soc Lond B Biol Sci. 2020 Jan 20;375(1790):20190188. doi: 10.1098/rstb.2019.0188. Epub 2019 Dec 2. Philos Trans R Soc Lond B Biol Sci. 2020. PMID: 31787039 Free PMC article.
-
Genome-Wide Epistasis Study of Cerebrospinal Fluid Hyperphosphorylated Tau in ADNI Cohort.Genes (Basel). 2023 Jun 23;14(7):1322. doi: 10.3390/genes14071322. Genes (Basel). 2023. PMID: 37510227 Free PMC article.
-
The False Dawn of Polygenic Risk Scores for Human Disease Prediction.J Pers Med. 2022 Jul 31;12(8):1266. doi: 10.3390/jpm12081266. J Pers Med. 2022. PMID: 36013215 Free PMC article.
References
-
- Kauffman SA. The Origins of Order. Oxford: Oxford University Press; 1993.
-
- Falconer DS, Mackay TFC. Introduction to Quantitative Genetics. 4. Essex, UK: Longman; 1996.
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
