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Editorial
. 2014 Aug;34(8):1607-8.
doi: 10.1161/ATVBAHA.114.304005.

New targets for atherothrombosis

Nigel Mackman  1
Affiliations
Editorial

New targets for atherothrombosis

Nigel Mackman. Arterioscler Thromb Vasc Biol. 2014 Aug.
No abstract available

Keywords: anticoagulation; atherosclerosis; thrombosis.

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Figures

Figure
Figure. Tissue factor and factor XII trigger atherothrombosis after atherosclerotic plaque rupture
Plaque tissue factor initiates a rapid activation of the coagulation cascade whereas factor XIIa amplifies the cascade and stabilizes the thrombus. Factor XII may be activated by a variety of agonists such as collagen, nucleic acids and/or inorganic polyphosphate. One would expect differences in efficacy and safety associated with inhibition of the different levels of the intrinsic pathway versus the extrinsic and common pathways.
See this image and copyright information in PMC

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