Antiretroviral restriction factors in mice

doi:10.1016/j.virusres.2014.07.002

Review

. 2014 Nov 26:193:130-4.

doi: 10.1016/j.virusres.2014.07.002. Epub 2014 Jul 10.

Antiretroviral restriction factors in mice

Smita Nair¹, Alan Rein²

Affiliations

¹ HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
² HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: reina@mail.nih.gov.

PMID: 25018022
PMCID: PMC4254267
DOI: 10.1016/j.virusres.2014.07.002

Review

Antiretroviral restriction factors in mice

Smita Nair et al. Virus Res. 2014.

. 2014 Nov 26:193:130-4.

doi: 10.1016/j.virusres.2014.07.002. Epub 2014 Jul 10.

Authors

Smita Nair¹, Alan Rein²

Affiliations

¹ HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
² HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: reina@mail.nih.gov.

PMID: 25018022
PMCID: PMC4254267
DOI: 10.1016/j.virusres.2014.07.002

Abstract

One of the most exciting areas in contemporary retrovirus research is the discovery of "restriction factors". These are cellular proteins that act after virus entry to inhibit infection by or replication of retroviruses (and other viruses and intracellular pathogens). We briefly discuss here three antiretroviral restriction factors in mice: Fv1, APOBEC3, and tetherin, touching on both biological and molecular aspects of these restriction systems.

Keywords: APOBEC3; Fv1 restriction; Murine leukemia virus; Retrovirus; Tetherin.

Published by Elsevier B.V.

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References

1. Andrew AJ, Miyagi E, Kao S, Strebel K. The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. Retrovirology. 2009;6:80. - PMC - PubMed
1. Barrett BS, Smith DS, Li SX, Guo K, Hasenkrug KJ, Santiago ML. A Single Nucleotide Polymorphism in Tetherin Promotes Retrovirus Restriction In Vivo. PLoS Pathog. 2012;8(3):e1002596. - PMC - PubMed
1. Bassin RH, Gerwin BI, Duran-Troise G, Gisselbrecht S, Rein A. Murine sarcoma virus pseudotypes acquire a determinant specifying N or B tropism from leukaemia virus during rescue. Nature. 1975;256(5514):223–225. - PubMed
1. Bassin RH, Gerwin BI, Levin JG, Duran-Troise G, Benjers BM, Rein A. Macromolecular requirements for abrogation of Fv-1 restriction by murine leukemia viruses. J Virol. 1980;35(2):287–297. - PMC - PubMed
1. Best S, Le Tissier P, Towers G, Stoye JP. Positional cloning of the mouse retrovirus restriction gene Fv1. Nature. 1996;382(6594):826–829. see comments. - PubMed

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[1] Andrew AJ, Miyagi E, Kao S, Strebel K. The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. Retrovirology. 2009;6:80. - PMC - PubMed

[2] Andrew AJ, Miyagi E, Kao S, Strebel K. The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. Retrovirology. 2009;6:80. - PMC - PubMed

[3] Barrett BS, Smith DS, Li SX, Guo K, Hasenkrug KJ, Santiago ML. A Single Nucleotide Polymorphism in Tetherin Promotes Retrovirus Restriction In Vivo. PLoS Pathog. 2012;8(3):e1002596. - PMC - PubMed

[4] Barrett BS, Smith DS, Li SX, Guo K, Hasenkrug KJ, Santiago ML. A Single Nucleotide Polymorphism in Tetherin Promotes Retrovirus Restriction In Vivo. PLoS Pathog. 2012;8(3):e1002596. - PMC - PubMed

[5] Bassin RH, Gerwin BI, Duran-Troise G, Gisselbrecht S, Rein A. Murine sarcoma virus pseudotypes acquire a determinant specifying N or B tropism from leukaemia virus during rescue. Nature. 1975;256(5514):223–225. - PubMed

[6] Bassin RH, Gerwin BI, Duran-Troise G, Gisselbrecht S, Rein A. Murine sarcoma virus pseudotypes acquire a determinant specifying N or B tropism from leukaemia virus during rescue. Nature. 1975;256(5514):223–225. - PubMed

[7] Bassin RH, Gerwin BI, Levin JG, Duran-Troise G, Benjers BM, Rein A. Macromolecular requirements for abrogation of Fv-1 restriction by murine leukemia viruses. J Virol. 1980;35(2):287–297. - PMC - PubMed

[8] Bassin RH, Gerwin BI, Levin JG, Duran-Troise G, Benjers BM, Rein A. Macromolecular requirements for abrogation of Fv-1 restriction by murine leukemia viruses. J Virol. 1980;35(2):287–297. - PMC - PubMed

[9] Best S, Le Tissier P, Towers G, Stoye JP. Positional cloning of the mouse retrovirus restriction gene Fv1. Nature. 1996;382(6594):826–829. see comments. - PubMed

[10] Best S, Le Tissier P, Towers G, Stoye JP. Positional cloning of the mouse retrovirus restriction gene Fv1. Nature. 1996;382(6594):826–829. see comments. - PubMed

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Antiretroviral restriction factors in mice

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Antiretroviral restriction factors in mice

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