Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Apr;141(4):575-89.
doi: 10.1007/s00432-014-1772-6. Epub 2014 Jul 9.

Cytokines: shifting the balance between glioma cells and tumor microenvironment after irradiation

Wei Zhou  1 , Zheng Jiang, Xingang Li, Yangyang Xu, Zhenyu Shao
Affiliations
Review

Cytokines: shifting the balance between glioma cells and tumor microenvironment after irradiation

Wei Zhou et al. J Cancer Res Clin Oncol. 2015 Apr.

Abstract

Malignant gliomas invariably recur after irradiation, showing radioresistance. Meanwhile, cranial irradiation can bring some risk for developing cognitive dysfunction. There is increasing evidence that cytokines play their peculiar roles in these processes. On the one hand, cytokines directly influence the progression of malignant glioma, promoting or suppressing tumor progression. On the other hand, cytokines indirectly contribute to the immunologic response against gliomas, exhibiting pro-inflammatory or immunosuppressive activities. We propose that cytokines are not simply unregulated products from tumor cells or immune cells, but mediators finely adjust the balance between glioma cells and tumor microenvironment after irradiation. The paper, therefore, focuses on the changes of cytokines after irradiation, analyzing how these mediate the response of tumor cells and normal cells to irradiation. In addition, cytokine-based immunotherapeutic strategies, accompanied with irradiation, for the treatment of gliomas are also discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Int J Cancer. 2005 Jun 10;115(2):202-13 - PubMed
    1. Brain Res. 1991 Dec 6;566(1-2):265-9 - PubMed
    1. Anticancer Res. 2000 Jan-Feb;20(1C):611-8 - PubMed
    1. J Biol Chem. 2003 Dec 19;278(51):51075-84 - PubMed
    1. Oncol Rep. 2010 Jun;23(6):1553-9 - PubMed

Publication types

LinkOut - more resources