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Review
. 2015 Aug 18:1617:113-25.
doi: 10.1016/j.brainres.2014.06.032. Epub 2014 Jul 5.

Inflammatory cytokine-associated depression

Francis E Lotrich  1
Affiliations
Review

Inflammatory cytokine-associated depression

Francis E Lotrich. Brain Res. .

Abstract

Inflammatory cytokines can sometimes trigger depression in humans, are often associated with depression, and can elicit some behaviors in animals that are homologous to major depression. Moreover, these cytokines can affect monoaminergic and glutamatergic systems, supporting an overlapping pathoetiology with major depression. This suggests that there could be a specific major depression subtype, inflammatory cytokine-associated depression (ICAD), which may require different therapeutic approaches. However, most people do not develop depression, even when exposed to sustained elevations in inflammatory cytokines. Thus several vulnerabilities and sources of resilience to inflammation-associated depression have been identified. These range from genetic differences in neurotrophic and serotonergic systems to sleep quality and omega-3 fatty acid levels. Replicating these sources of resilience as treatments could be one approach for preventing "ICAD". This article is part of a Special Issue entitled SI: Neuroimmunology in Health And Disease.

Keywords: Cytokine; Depression; Interferon; Interleukin; Mood; Vulnerability.

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References

    1. Krausr MR, Schafer A, Csef H, Scheurlen M. Psychiatric side effects of pegylated interferon alfa-2b as compared to conventional interferon alfa-2b in patients with chronic hepatitis C. World Journal of Gastroenterology. 2005;11(12):1769–74. - PMC - PubMed
    1. Loftis JM, Hauser P. The phenomenology and treatment of interferon-induced depression. J Affect Disord. 2004;82(2):175–90. - PubMed
    1. Asnis GM, De La Garza R., 2nd Interferon-induced depression in chronic hepatitis C: a review of its prevalence, risk factors, biology, and treatment approaches. J Clin Gastroenterol. 2006;40(4):322–35. - PubMed
    1. Schaefer M, Engelbrecht MA, Gut O, et al. Interferon alpha (IFNalpha) and psychiatric syndromes: a review. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26(4):731–46. - PubMed
    1. Trask PC, Esper P, Riba M, Redman B. Psychiatric side effects of interferon therapy: prevalence, proposed mechanisms, and future directions. J Clin Oncol. 2000;18(11):2316–26. - PubMed

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