Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun;51(6):273-8.
doi: 10.1016/j.arbres.2014.03.019. Epub 2014 Jul 2.

Association Between Chronic Respiratory Diseases and Helicobacter pylori: A Meta-Analysis

[Article in English, Spanish]
Lijie Wang  1 , Yan Guan  2 , Yan Li  1 , Xiuju Liu  2 , Yakun Zhang  2 , Fuxia Wang  1 , Lingling Kong  2 , Qisen Guo  3
Affiliations
Review

Association Between Chronic Respiratory Diseases and Helicobacter pylori: A Meta-Analysis

[Article in English, Spanish]
Lijie Wang et al. Arch Bronconeumol. 2015 Jun.

Abstract

Background: The prevalence of chronic respiratory diseases (CRDs), including chronic bronchitis and chronic obstructive pulmonary disease (COPD), has increased significantly over the past decades. Several studies suggest that Helicobacter pylori infection may be related to the development of CRDs, but the results were not consistent. We carried out a meta-analysis to evaluate the potential association of H.pylori infection with CRDs.

Methods: We conducted a systematic literature search in PubMed, Embase, Ovid, Google Scholar and CNKI from inception to October 31, 2013. The following search terms were used: "chronic respiratory disease," "chronic bronchitis," "chronic obstructive pulmonary disease" or "COPD" in combination with "Helicobacter pylori" or "Campylobacter pylori." According to established inclusion criteria, we selected all eligible published papers and then extracted essential data. To evaluate the association of H.pylori with chronic bronchitis and COPD, an overall analysis and subgroup analyses were conducted.

Results: A total of 9 case-control studies comprising 782 cases and 815 controls were included in the study. Pooled ORs were 2.30 (95%CI: 1.85-2.85) in the overall analysis, 2.90 (95%CI: 2.04-4.13) in the chronic bronchitis subgroup, and 2.11 (95%CI: 1.35-3.29) in the COPD subgroup.

Conclusions: The results of the overall analysis and subgroup analyzed suggest a significant association between H.pylori and CRDs. Further studies are needed to clarify the pathogenetic mechanisms involved.

Keywords: Bronquitis crónica; Chronic bronchitis; Chronic obstructive pulmonary disease; Chronic respiratory diseases; Enfermedad pulmonar obstructiva crónica; Enfermedades respiratorias crónicas; Helicobacter pylori; Meta-analysis; Metaanálisis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

MeSH terms

Substances