Role of autoimmune responses in periodontal disease
- PMID: 24963400
- PMCID: PMC4055614
- DOI: 10.1155/2014/596824
Role of autoimmune responses in periodontal disease
Abstract
Periodontal diseases are characterized by localized infections and inflammatory conditions that directly affect teeth supporting structures which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidences of involvement of immunopathology have been reported in periodontal disease. Bacteria in the dental plaque induce antibody formation. Autoreactive T cells, natural killer cells, ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to have an important role in the autoimmune component of periodontal disease. The present review describes the involvement of autoimmune responses in periodontal diseases and also the mechanisms underlying these responses. This review is an attempt to throw light on the etiopathogenesis of periodontal disease highlighting the autoimmunity aspect of the etiopathogenesis involved in the initiation and progression of the disease. However, further clinical trials are required to strengthen the role of autoimmunity as a cause of periodontal disease.
Similar articles
-
Autoimmunity-Basics and link with periodontal disease.Autoimmun Rev. 2017 Jan;16(1):64-71. doi: 10.1016/j.autrev.2016.09.013. Epub 2016 Sep 21. Autoimmun Rev. 2017. PMID: 27664383 Review.
-
Autoimmune responses in periodontal diseases.Autoimmun Rev. 2011 May;10(7):426-31. doi: 10.1016/j.autrev.2010.04.005. Epub 2011 Jan 20. Autoimmun Rev. 2011. PMID: 21256252 Review.
-
Periodontal Disease as a Risk Factor for Rheumatoid Arthritis: A Systematic Review.JBI Libr Syst Rev. 2012;10(42 Suppl):1-12. doi: 10.11124/jbisrir-2012-288. JBI Libr Syst Rev. 2012. PMID: 27820156
-
Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.J Clin Periodontol. 2018 Jun;45 Suppl 20:S219-S229. doi: 10.1111/jcpe.12951. J Clin Periodontol. 2018. PMID: 29926500
-
Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.J Periodontol. 2018 Jun;89 Suppl 1:S237-S248. doi: 10.1002/JPER.17-0733. J Periodontol. 2018. PMID: 29926943 Review.
Cited by
-
In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review.Pharmaceutics. 2022 Sep 21;14(10):1997. doi: 10.3390/pharmaceutics14101997. Pharmaceutics. 2022. PMID: 36297434 Free PMC article. Review.
-
Fixed Prosthetic Restorations and Periodontal Health: A Narrative Review.J Funct Biomater. 2022 Feb 1;13(1):15. doi: 10.3390/jfb13010015. J Funct Biomater. 2022. PMID: 35225978 Free PMC article. Review.
-
A Review of Cardiac Manifestations in Patients With Systemic Lupus Erythematosus and Antiphospholipid Syndrome With Focus on Endocarditis.Cureus. 2022 Jan 28;14(1):e21698. doi: 10.7759/cureus.21698. eCollection 2022 Jan. Cureus. 2022. PMID: 35242470 Free PMC article. Review.
-
Nuclear aberrations in the gingival epithelium of patients with chronic periodontitis.J Indian Soc Periodontol. 2023 Jul-Aug;27(4):374-380. doi: 10.4103/jisp.jisp_18_22. Epub 2023 Jul 1. J Indian Soc Periodontol. 2023. PMID: 37593557 Free PMC article.
-
Cytomorphometric Analysis of Inflammation Dynamics in the Periodontium Following the Use of Fixed Dental Prostheses.Molecules. 2020 Oct 12;25(20):4650. doi: 10.3390/molecules25204650. Molecules. 2020. PMID: 33053882 Free PMC article.
References
-
- Newman MG, Takei H, Klokkevold PR, Carranza FA. Caranza,s Clinical Periodontology. 10th edition. Elsevier; 2006.
-
- Jiang S, Lechler RI. Regulatory T cells in the control of transplantation tolerance and autoimmunity. American Journal of Transplantation. 2003;3(5):516–524. - PubMed
-
- Anusaksathien O, Dolby AE. Autoimmunity in periodontal disease. Journal of Oral Pathology and Medicine. 1991;20(3):101–107. - PubMed
-
- Anusaksathien O, Singh G, Matthews N, Dolby AE. Autoimmunity to collagen in adult periodontal disease: immunoglobulin classes in sera and tissue. Journal of Periodontal Research. 1992;27(1):55–61. - PubMed
-
- Hahn CL, Schenkein HA, Tew JG. Polyclonal B cell acivators and in vitro induction of auto antibody reactive with collagen. Journal of Periodontal Research. 1997;32:608–613. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
