Bupivacaine liposomal versus bupivacaine: comparative review

doi:10.1310/hpj4906-539

. 2014 Jun;49(6):539-43.

doi: 10.1310/hpj4906-539.

Bupivacaine liposomal versus bupivacaine: comparative review

John Noviasky¹, Deirdre P Pierce², Karen Whalen³, Roy Guharoy⁴, Kenneth Hildreth⁵

Affiliations

¹ Clinical Coordinator, Upstate University Hospital at Community General , Syracuse, New York.
² Assistant Professor of Pharmacy Practice, St. John Fisher College, Wegmans School of Pharmacy , Rochester, New York.
³ Drug Information Pharmacist, St. Joseph's Hospital Health Center , Syracuse, New York.
⁴ Professor of Medicine, University of Massachusetts Medical School , Worcester, Massachusetts.
⁵ Anesthesiologist, Upstate University Hospital at Community General , Syracuse, New York .

PMID: 24958971
PMCID: PMC4062733
DOI: 10.1310/hpj4906-539

Bupivacaine liposomal versus bupivacaine: comparative review

John Noviasky et al. Hosp Pharm. 2014 Jun.

. 2014 Jun;49(6):539-43.

doi: 10.1310/hpj4906-539.

Authors

John Noviasky¹, Deirdre P Pierce², Karen Whalen³, Roy Guharoy⁴, Kenneth Hildreth⁵

Affiliations

¹ Clinical Coordinator, Upstate University Hospital at Community General , Syracuse, New York.
² Assistant Professor of Pharmacy Practice, St. John Fisher College, Wegmans School of Pharmacy , Rochester, New York.
³ Drug Information Pharmacist, St. Joseph's Hospital Health Center , Syracuse, New York.
⁴ Professor of Medicine, University of Massachusetts Medical School , Worcester, Massachusetts.
⁵ Anesthesiologist, Upstate University Hospital at Community General , Syracuse, New York .

PMID: 24958971
PMCID: PMC4062733
DOI: 10.1310/hpj4906-539

Abstract

Bupivacaine liposomal injection was recently approved by the US Food and Drug Administration (FDA) as a local anesthetic for use in management of postsurgical pain in adults. When compared to placebo, bupivacaine liposomal decreases postoperative pain and opioid use. This review examines the efficacy of bupivacaine liposomal when compared to conventional bupivacaine ± epinephrine using published and unpublished data provided to the FDA by the manufacturer.

Keywords: bupivacaine; bupivacaine liposomal; formulary; pharmacoeconomics.

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Figures

**Figure 1.**
Bupivicaine liposomal mean pain intensity (PI) versus time plot for hemorrhoidectomy study showing no difference in effect on pain measures compared to placebo after 24 hours.

**Figure 2.**
Mean pain intensity (PI) versus time plot for bunionectomy study showing no difference in effect on pain measures compared to placebo after 24 hours.

See this image and copyright information in PMC

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References

1. Pacira Pharmaceuticals Inc. News release. November1, 2012. http://investor.pacira.com/phoenix.zhtml?c=220759&p=irol-newsArticle&ID=... Accessed January2, 2013
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[1] Pacira Pharmaceuticals Inc. News release. November1, 2012. http://investor.pacira.com/phoenix.zhtml?c=220759&p=irol-newsArticle&ID=... Accessed January2, 2013

[2] Pacira Pharmaceuticals Inc. News release. November1, 2012. http://investor.pacira.com/phoenix.zhtml?c=220759&p=irol-newsArticle&ID=... Accessed January2, 2013

[3] Candiotti K. Liposomal bupivacaine: An innovative nonopioid local analgesic for the management of postsurgical pain. Pharmacotherapy. 2012;32:19S–26S - PubMed

[4] Candiotti K. Liposomal bupivacaine: An innovative nonopioid local analgesic for the management of postsurgical pain. Pharmacotherapy. 2012;32:19S–26S - PubMed

[5] Chahar P, Cummings KC. Liposomal bupivacaine: A review of a new bupivacaine formulation. J Pain Res. 2012;5:257–264 - PMC - PubMed

[6] Chahar P, Cummings KC. Liposomal bupivacaine: A review of a new bupivacaine formulation. J Pain Res. 2012;5:257–264 - PMC - PubMed

[7] New opportunities for hospitals to improve economic efficiency and patient outcomes: The case of Exparel, a long-acting non-opioid local analgesic. A Frost & Sullivan White Paper. 2012. http://www.frost.com/prod/servlet/cpo/252218999 Accessed April2, 2014

[8] New opportunities for hospitals to improve economic efficiency and patient outcomes: The case of Exparel, a long-acting non-opioid local analgesic. A Frost & Sullivan White Paper. 2012. http://www.frost.com/prod/servlet/cpo/252218999 Accessed April2, 2014

[9] Simone A. Center for Drug Evaluation and Research Clinical Review, NDA 022-496. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/022496Orig1s000Me... Accessed April2, 2014

[10] Simone A. Center for Drug Evaluation and Research Clinical Review, NDA 022-496. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/022496Orig1s000Me... Accessed April2, 2014

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Bupivacaine liposomal versus bupivacaine: comparative review

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Bupivacaine liposomal versus bupivacaine: comparative review

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