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Review
. 2014 Aug:26:283-94.
doi: 10.1016/j.meegid.2014.05.030. Epub 2014 Jun 14.

Genome analysis of non-human primate polyomaviruses

Bernhard Ehlers  1 , Ugo Moens  2
Affiliations
Review

Genome analysis of non-human primate polyomaviruses

Bernhard Ehlers et al. Infect Genet Evol. 2014 Aug.

Abstract

Polyomaviruses have so far only been isolated from mammals and birds. Typical for all members of this family is their double-stranded genome of approximately 5000 base-pairs which can be divided into an early region encoding at least two functional proteins, the large and small tumor antigens, and a late region encompassing genes for the capsid proteins VP1 and VP2. During the last 10 years several novel polyomaviruses have been described in non-human primates and man. This review compares the non-human primate polyomavirus genomes that have been completely sequenced with each other and with the genomes of human polyomaviruses. We predict the presence of protein- and microRNA-encoding sequences. Our analyses demonstrate that several genetically distinct groups of non-human primate polyomaviruses exist, that different polyomaviruses can infect the same non-human primate species but that most of their proteins display highly similar domains and motifs, indicating conservation of key functions.

Keywords: Agno; Alto; Large T; Small T; VP1; VP2.

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