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Comparative Study
. 2014 Jul:28:177-86.
doi: 10.1016/j.healthplace.2014.05.003. Epub 2014 Jun 5.

Multilevel examination of the association of urbanization with inflammation in Chinese adults

Amanda L Thompson  1 , Kelly M Houck  2 , Linda Adair  3 , Penny Gordon-Larsen  4 , Barry Popkin  5
Affiliations
Comparative Study

Multilevel examination of the association of urbanization with inflammation in Chinese adults

Amanda L Thompson et al. Health Place. 2014 Jul.

Abstract

We examine the associations between overall urbanicity and specific physical and social components of community-level urbanization with C-reactive protein (CRP) in adults participating in the China Health and Nutrition Study. Higher overall urbanicity and environment-related urbanicity component scores, including education, housing quality, and access to markets, were associated with elevated CRP in multilevel models controlling for clustering by community. These associations differed by age and gender and persisted after controlling for individual-level anthropometric, diet, and pathogenic risk factors. These results highlight the importance of place in relation to inflammation across the spectrum of rural and urban environments.

Keywords: C-reactive protein; China; Inflammation; Neighborhood health; Urbanization.

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Figures

Figure 1
Figure 1. Predicted probability of elevated CRP (3–10mg/L) across tertiles of urbanization by age strata and sex
*significant urbanicity effect within age strata, p<0.05.
Figure 2
Figure 2. Unadjusted and adjusted sex- and age-strata differences in the predicted probabilities of moderately elevated CRP with higher urbanization component scores
*significant slope (in age strata) in multilevel logistic model, controlling for clustering by community, p<0.05. † significant slope (in age strata) in adjusted model controlling for overweight, high waist circumference, high fat diet, physical activity, smoking, income, education, infectious illness symptoms, region and clustering by community, p<0.05.
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