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. 2014:2014:542385.
doi: 10.1155/2014/542385. Epub 2014 Apr 27.

Evaluation of anticonvulsant, sedative, anxiolytic, and phytochemical profile of the methanol extract from the aerial parts of Swertia corymbosa (Griseb.) wight ex C.B. Clarke

G Mahendran  1 , G Thamotharan  2 , S Sengottuvelu  2 , V Narmatha Bai  1
Affiliations

Evaluation of anticonvulsant, sedative, anxiolytic, and phytochemical profile of the methanol extract from the aerial parts of Swertia corymbosa (Griseb.) wight ex C.B. Clarke

G Mahendran et al. Biomed Res Int. 2014.

Abstract

The objective of the present study was to evaluate the anxiolytic, antidepressant, and anticonvulsant activity of the methanolic extract of Swertia corymbosa (SCMeOH). After acute toxicity test, oral treatment with SCMeOH at doses of 125, 250, and 500 mg/kg behavioral models of open field, elevated-plus-maze, actophotometer, rotarod, pentylenetetrazole, isoniazid, and maximal electroshock induced seizure models were utilized. In open field test, SCMeOH (125, 250, and 500 mg/kg) (P < 0.01, P < 0.001) increased the number of rearings. However, the number of central motor and ambulation (P < 0.01, P < 0.001) were reduced. Likewise, the number of entries and the time spent in open arm were increased while the number of locomotion was decreased (P < 0.001) in elevated-plus-maze and actophotometer test, respectively. SCMeOH (125-500 mg/kg) protected the mice against the pentylenetetrazole and isoniazid induced convulsions; it causes significant (P < 0.01 and P < 0.001) dose dependent increase in latency of convulsion. Treatment with SCMeOH reduced the duration of the tonic hind limb extension induced by electroshock. Two major compounds such as gentiopicroside and swertianin were analyzed by HPLC system.

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Figures

Figure 1
Figure 1
Effect of oral administration of Swertia corymbosa methanolic extract (SCMeOH) on the time spent in open arms (TOA) and time spent in closed arm (EOA) by rat exposed to EPM. *P < 0.01 and **P < 0.001 indicate significant difference from control.
Figure 2
Figure 2
Effect of oral administration of Swertia corymbosa methanolic extract (SCMeOH) on the number of entries in open and closed arms by rats exposed to EPM. *P < 0.01 and **P < 0.001 indicate significant difference from control.
Figure 3
Figure 3
Effect of oral administration of Swertia corymbosa methanolic extract (SCMeOH) on the total of entries in open and closed arms by rats exposed to EPM. *P < 0.01 and **P < 0.001 indicate significant difference from control.
Figure 4
Figure 4
Effect of oral administration of Swertia corymbosa methanolic extract (SCMeOH) on the central locomotion ambulation and rearings of mice exposed in open field test. *P < 0.01 and **P < 0.001 indicate significant difference from control.
Figure 5
Figure 5
(a) HPLC—chromatograms of gentiopicroside and swertianin. (b) HPLC—chromatograms of methanol extract from Swertia corymbosa (SCMeOH).
Figure 6
Figure 6
Structures of gentiopicroside and swertianin.
See this image and copyright information in PMC

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