Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate

doi:10.1038/nmat3980

Review

. 2014 Jun;13(6):558-69.

doi: 10.1038/nmat3980.

Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate

Matthew J Dalby¹, Nikolaj Gadegaard², Richard O C Oreffo³

Affiliations

¹ Centre for Cell Engineering, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
² Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, Scotland, UK.
³ Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, UK.

PMID: 24845995
DOI: 10.1038/nmat3980

Review

Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate

Matthew J Dalby et al. Nat Mater. 2014 Jun.

. 2014 Jun;13(6):558-69.

doi: 10.1038/nmat3980.

Authors

Matthew J Dalby¹, Nikolaj Gadegaard², Richard O C Oreffo³

Affiliations

¹ Centre for Cell Engineering, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
² Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, Scotland, UK.
³ Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, UK.

PMID: 24845995
DOI: 10.1038/nmat3980

Abstract

Stem cells respond to nanoscale surface features, with changes in cell growth and differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical features with integrin receptors in the cells' focal adhesions alters how the cells adhere to materials surfaces, and defines cell fate through changes in both cell biochemistry and cell morphology. In this Review, we discuss how cell adhesions interact with nanotopography, and we provide insight as to how materials scientists can exploit these interactions to direct stem cell fate and to understand how the behaviour of stem cells in their niche can be controlled. We expect knowledge gained from the study of cell-nanotopography interactions to accelerate the development of next-generation stem cell culture materials and implant interfaces, and to fuel discovery of stem cell therapeutics to support regenerative therapies.

PubMed Disclaimer

Cited by

Exploiting cell-mediated contraction and adhesion to structure tissues in vitro.
Wudebwe UN, Bannerman A, Goldberg-Oppenheimer P, Paxton JZ, Williams RL, Grover LM. Wudebwe UN, et al. Philos Trans R Soc Lond B Biol Sci. 2015 Feb 5;370(1661):20140200. doi: 10.1098/rstb.2014.0200. Philos Trans R Soc Lond B Biol Sci. 2015. PMID: 25533106 Free PMC article.
Cell Adhesion Minimization by a Novel Mesh Culture Method Mechanically Directs Trophoblast Differentiation and Self-Assembly Organization of Human Pluripotent Stem Cells.
Okeyo KO, Kurosawa O, Yamazaki S, Oana H, Kotera H, Nakauchi H, Washizu M. Okeyo KO, et al. Tissue Eng Part C Methods. 2015 Oct;21(10):1105-15. doi: 10.1089/ten.TEC.2015.0038. Epub 2015 Jun 5. Tissue Eng Part C Methods. 2015. PMID: 25914965 Free PMC article.
Biomaterial-mediated strategies targeting vascularization for bone repair.
García JR, García AJ. García JR, et al. Drug Deliv Transl Res. 2016 Apr;6(2):77-95. doi: 10.1007/s13346-015-0236-0. Drug Deliv Transl Res. 2016. PMID: 26014967 Free PMC article. Review.
Biofabrication offers future hope for tackling various obstacles and challenges in tissue engineering and regenerative medicine: A Perspective.
Mir TA, Iwanaga S, Kurooka T, Toda H, Sakai S, Nakamura M. Mir TA, et al. Int J Bioprint. 2018 Dec 31;5(1):153. doi: 10.18063/ijb.v5i1.153. eCollection 2019. Int J Bioprint. 2018. PMID: 32596529 Free PMC article.
A Review of the Effect of a Nanostructured Thin Film Formed by Titanium Carbide and Titanium Oxides Clustered around Carbon in Graphitic Form on Osseointegration.
Scandurra R, Scotto d'Abusco A, Longo G. Scandurra R, et al. Nanomaterials (Basel). 2020 Jun 24;10(6):1233. doi: 10.3390/nano10061233. Nanomaterials (Basel). 2020. PMID: 32599955 Free PMC article. Review.

See all "Cited by" articles

References

1. J Cell Sci. 2003 May 15;116(Pt 10):1881-92 - PubMed
1. ACS Nano. 2012 Nov 27;6(11):10239-49 - PubMed
1. Acta Biomater. 2013 May;9(5):6369-80 - PubMed
1. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16565-70 - PubMed
1. J Biomed Mater Res. 2000 Feb;49(2):155-66 - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] J Cell Sci. 2003 May 15;116(Pt 10):1881-92 - PubMed

[2] J Cell Sci. 2003 May 15;116(Pt 10):1881-92 - PubMed

[3] ACS Nano. 2012 Nov 27;6(11):10239-49 - PubMed

[4] ACS Nano. 2012 Nov 27;6(11):10239-49 - PubMed

[5] Acta Biomater. 2013 May;9(5):6369-80 - PubMed

[6] Acta Biomater. 2013 May;9(5):6369-80 - PubMed

[7] Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16565-70 - PubMed

[8] Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16565-70 - PubMed

[9] J Biomed Mater Res. 2000 Feb;49(2):155-66 - PubMed

[10] J Biomed Mater Res. 2000 Feb;49(2):155-66 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate

Affiliations

Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical