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Review
. 2014 Oct;38(5):598-603.
doi: 10.1016/j.clinre.2014.04.004. Epub 2014 May 15.

Protein expression of hypoxia-inducible factor-1 alpha and hepatocellular carcinoma: a systematic review with meta-analysis

Shiyi Cao  1 , Shengli Yang  2 , Chao Wu  2 , Yunxia Wang  1 , Jianxin Jiang  3 , Zuxun Lu  4
Affiliations
Review

Protein expression of hypoxia-inducible factor-1 alpha and hepatocellular carcinoma: a systematic review with meta-analysis

Shiyi Cao et al. Clin Res Hepatol Gastroenterol. 2014 Oct.

Abstract

Purpose: To investigate the relationship of protein expression of hypoxia-inducible factor-1 alpha (HIF-1α) with clinicopathological factors and prognosis of hepatocellular carcinoma (HCC).

Methods: PubMed and Embase were searched from their inception through August 2013 for studies that reported the association between protein expression of HIF-1α and HCC. Random effects meta-analyses were used to summarize the odds ratios (ORs) and 95% confidence intervals (CIs).

Results: Eight studies involving 851 patients with HCC were included. Protein expression level of HIF-1α was not found to be related with capsule formation, cirrhosis, tumor size, and tumor differentiation of HCC, except vascular invasion. The positive association between HIF-1α expression and vascular invasion of HCC was statistically significant (OR: 2.04, 95% CI: 1.31-3.18). As a prognostic factor, a high level of HIF-1α expression would be associated with a poor disease-free survival (OR: 2.10, 95% CI: 1.48-2.97).

Conclusion: Higher level of HIF-1α expression may indicate a bigger possibility of vascular invasion and a poorer prognosis of HCC.

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