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Comparative Study
. 2014:2014:974503.
doi: 10.1155/2014/974503. Epub 2014 Apr 14.

Leptin levels and nutritional status of indigenous Tepehuán and Mestizo subjects in Durango, Mexico

Dealmy Delgadillo Guzmán  1 , Laurence Annie Marchat Marchau  2 , José L Reyes  3 , Verónica Loera Castañeda  1 , Martha Sosa Macías  1 , Jessica García Vivas  2 , Ismael Lares Asseff  4
Affiliations
Comparative Study

Leptin levels and nutritional status of indigenous Tepehuán and Mestizo subjects in Durango, Mexico

Dealmy Delgadillo Guzmán et al. Dis Markers. 2014.

Abstract

The aim of this study was to assess differences in nutritional status and their association with circulating leptin levels in the indigenous Tepehuán people of Mezquital Durango and Mestizo populations of Durango City, Mexico. A group of 128 volunteers aged 18 through 59 years were recruited for the study: 60 indigenous Tepehuán from Mezquital and 68 Mestizo individuals from Durango City. The classification of nutritional status was through body mass index (BMI). Clinical evaluations, including anthropometry and lipid profiles, were performed to ascertain the health of the participants. Circulating leptin levels were determined in blood samples after at 08 hours of fasting. The healthy subjects were classified according to BMI: 32 Tepehuán and 30 Mestizo subjects were of normal weight (NW), and 28 Tepehuán and 38 Mestizo subjects were overweight or obese (OW/O). Both NW and OW/O Tepehuán subjects showed lower leptin concentrations than the comparable Mestizo subjects. Statistical analysis showed a negative Pearson's correlation (r = -0.5; P < 0.05) between BMI and leptin levels in NW Tepehuán subjects, but no significant correlation was found in other groups. The differences found in Tepehuán compared with Mestizo subjects might be explained by poor nutritional status, which leads to scarce adipose tissue and low levels of leptin synthesis. Leptin concentration and its relationship to BMI are associated with ethnicity.

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Figures

Figure 1
Figure 1
Comparison of circulating leptin levels in Tepehuán and Mestizo subjects according to their nutritional status. Distribution of the data is significantly different among the four subgroups according to ANOVA test (P < 0.0001). Moreover, analysis of the data by the Tukey-Kramer multiple comparisons test evidenced significant differences between NW Tepehuán and NW Mestizo, OW/O Tepehuán and OW/O Mestizo, and NW Mestizo and OW/O Mestizo subjects. *P < 0.05; **P < 0.01; ***P < 0.001. NW: normal weight; OW/O: overweight/obese.
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