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. 2014 May 9;344(6184):588-9.

doi: 10.1126/science.1254990.

AIDS/HIV. Host controls of HIV neutralizing antibodies

Barton F Haynes¹, Laurent Verkoczy

Affiliations

PMID: 24812389
PMCID: PMC4162091
DOI: 10.1126/science.1254990

AIDS/HIV. Host controls of HIV neutralizing antibodies

Barton F Haynes et al. Science. 2014.

. 2014 May 9;344(6184):588-9.

doi: 10.1126/science.1254990.

Authors

Barton F Haynes¹, Laurent Verkoczy

Affiliation

¹ Duke Human Vaccine Institute, Departments of Medicine, Immunology and Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

PMID: 24812389
PMCID: PMC4162091
DOI: 10.1126/science.1254990

Abstract

The unusual traits of broadly neutralizing antibodies for HIV-1 are stimulating new strategies to induce their production through vaccination.

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Figures

Figure 1. Eliciting broadly neutralizing antibodies to HIV-1
(A) During chronic HIV-1 infection of an individual, a rare B cell clonal lineage that produces a bnAb can emerge and survive after a long antibody maturation process in which large numbers of somatic mutations have accumulated. (B) In the setting of vaccination, B cells capable of generating bnAbs may be present at low frequency, along with higher-frequency non-bnAb B cells. Upon immunization, responding B cells differentiate into plasma cells, but non–bnAb-producing B cells are dominant. (C) The goal of successful immunization for bnAb induction is to use immunogens that specifically and selectively target the rare bnAb-producing B cell precursors and drive those lineages to become sufficiently dominant to produce protective plasma and tissue fluid bnAbs.

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