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. 1989 Nov;68(3):434-5.

Inhibition of murine B-lymphocyte proliferation by the novel immunosuppressive drug FK-506

P Walliser  1 , C R Benzie, J E Kay
Affiliations

Inhibition of murine B-lymphocyte proliferation by the novel immunosuppressive drug FK-506

P Walliser et al. Immunology. 1989 Nov.

Abstract

The novel immunosuppressive drug FK-506 inhibits both cell-mediated and humoral immunity in vivo and suppresses T-lymphocyte activation at nanamolar concentrations in vitro. We report here that FK-506 also inhibits the in vitro proliferation of murine B lymphocytes induced by goat antimouse IgM (GaMIgM), although it does not affect the induction of proliferation by bacterial lipopolysaccharide (LPS). The action of FK-506 on B-lymphocyte proliferation thus resembles that of cyclosporin A, further strengthening the correlation between the action of the two immunosuppressive drugs previously reported for T-lymphocyte activation.

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