doi: 10.1002/j.1460-2075.1989.tb08461.x.
The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc
Affiliations
- PMID: 2479541
- PMCID: PMC401388
- DOI: 10.1002/j.1460-2075.1989.tb08461.x
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The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc
EMBO J.
1989 Oct.
Abstract
The Drosophila segmentation gene, hairy (h), acts to regulate embryonic segmentation and bristle pattern. We present the DNA sequence of the h gene and of h cDNAs, thereby deducing the organization of the h transcripts. The h gene encodes a 337 amino acid protein that acts in both embryonic segmentation and adult bristle patterning. The h protein includes a domain that shows extensive similarity to a domain of the proto-oncogene N-myc that may be involved in DNA binding and/or protein dimerization. We discuss mechanisms of h action as a transcriptional regulator.
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