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. 2014 Jun;31(6):2820-6.
doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.

Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma

Katarzyna Augoff  1 , Anita Hryniewicz-Jankowska  2 , Renata Tabola  1 , Leszek Czapla  1 , Piotr Szelachowski  1 , Jaroslaw Wierzbicki  3 , Krzysztof Grabowski  1 , Aleksander F Sikorski  2
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Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma

Katarzyna Augoff et al. Oncol Rep. 2014 Jun.

Abstract

To better understand the role of membrane-associated proteolytic systems in the development of esophageal cancer, we studied the expression of two serine proteases, fibroblast activation protein-α (FAP-α) and dipeptidyl peptidase IV (DPPIV) and three metalloproteinases, matrix metalloproteinase (MMP)-2, MMP-9 and MT1-MMP in 24 primary esophageal squamous cell carcinoma (ESCC) tissues and paired non-cancer tissues. Using reverse-transcription PCR, western blotting and zymography, we showed that both serine proteases and all three metalloproteinases were highly altered in ESCC. A positive correlation between the expression of FAP-α and DPPIV and the activity of both gelatinases was found. This may indicate that these proteolytic systems are tightly linked to each other and collectively are involved in the process of ECM degradation that facilitates cancer cell invasion and metastasis.

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