Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates

doi:10.3389/fendo.2014.00043

Review

. 2014 Apr 7:5:43.

doi: 10.3389/fendo.2014.00043. eCollection 2014.

Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates

Andreas Hoeflich¹, Elisa Wirthgen², Robert David³, Carl Friedrich Classen⁴, Marion Spitschak¹, Julia Brenmoehl¹

Affiliations

¹ Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN) , Dummerstorf , Germany.
² Ligandis GbR , Gülzow , Germany.
³ Reference and Translation Center for Cardiac Stem Cell Therapy , Rostock , Germany.
⁴ Pediatric Oncology, University Children's Hospital , Rostock , Germany.

PMID: 24778626
PMCID: PMC3985015
DOI: 10.3389/fendo.2014.00043

Review

Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates

Andreas Hoeflich et al. Front Endocrinol (Lausanne). 2014.

. 2014 Apr 7:5:43.

doi: 10.3389/fendo.2014.00043. eCollection 2014.

Authors

Andreas Hoeflich¹, Elisa Wirthgen², Robert David³, Carl Friedrich Classen⁴, Marion Spitschak¹, Julia Brenmoehl¹

Affiliations

¹ Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN) , Dummerstorf , Germany.
² Ligandis GbR , Gülzow , Germany.
³ Reference and Translation Center for Cardiac Stem Cell Therapy , Rostock , Germany.
⁴ Pediatric Oncology, University Children's Hospital , Rostock , Germany.

PMID: 24778626
PMCID: PMC3985015
DOI: 10.3389/fendo.2014.00043

Abstract

IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3-8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and also has been provided as a protective element in earlier stages of multistage colon carcinogenesis (10). Therefore, it is crucial to understand the factors that determine expression patterns of IGFBP-2 under normal and malignant conditions. The present review provides a comprehensive update of known factors that have an impact on expression of IGFBP-2.

Keywords: IGFBP-2; estradiol; peptide hormones; steroids; vertebrates.

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References

1. Binkert C, Landwehr J, Mary JL, Schwander J, Heinrich G. Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2). EMBO J (1989) 8:2497–502 - PMC - PubMed
1. Zhang W, Fuller G. IGFBP2 as a brain tumor oncogene. Cancer Biol Ther (2007) 6:995–6 - PubMed
1. Chi F, Wu R, Zeng YC, Xing R, Liu Y. Circulation insulin-like growth factor peptides and colorectal cancer risk: an updated systematic review and meta-analysis. Mol Biol Rep (2013) 40:3583–9010.1007/s11033-012-2432-z - DOI - PubMed
1. Rowlands MA, Gunnell D, Harris R, Vatten LJ, Holly JM, Martin RM. Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis. Int J Cancer (2009) 124:2416–2910.1002/ijc.24202 - DOI - PMC - PubMed
1. Fukushima T, Kataoka H. Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma. Anticancer Res (2007) 27:3685–92 - PubMed

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[1] Binkert C, Landwehr J, Mary JL, Schwander J, Heinrich G. Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2). EMBO J (1989) 8:2497–502 - PMC - PubMed

[2] Binkert C, Landwehr J, Mary JL, Schwander J, Heinrich G. Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2). EMBO J (1989) 8:2497–502 - PMC - PubMed

[3] Zhang W, Fuller G. IGFBP2 as a brain tumor oncogene. Cancer Biol Ther (2007) 6:995–6 - PubMed

[4] Zhang W, Fuller G. IGFBP2 as a brain tumor oncogene. Cancer Biol Ther (2007) 6:995–6 - PubMed

[5] Chi F, Wu R, Zeng YC, Xing R, Liu Y. Circulation insulin-like growth factor peptides and colorectal cancer risk: an updated systematic review and meta-analysis. Mol Biol Rep (2013) 40:3583–9010.1007/s11033-012-2432-z - DOI - PubMed

[6] Chi F, Wu R, Zeng YC, Xing R, Liu Y. Circulation insulin-like growth factor peptides and colorectal cancer risk: an updated systematic review and meta-analysis. Mol Biol Rep (2013) 40:3583–9010.1007/s11033-012-2432-z - DOI - PubMed

[7] Rowlands MA, Gunnell D, Harris R, Vatten LJ, Holly JM, Martin RM. Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis. Int J Cancer (2009) 124:2416–2910.1002/ijc.24202 - DOI - PMC - PubMed

[8] Rowlands MA, Gunnell D, Harris R, Vatten LJ, Holly JM, Martin RM. Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis. Int J Cancer (2009) 124:2416–2910.1002/ijc.24202 - DOI - PMC - PubMed

[9] Fukushima T, Kataoka H. Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma. Anticancer Res (2007) 27:3685–92 - PubMed

[10] Fukushima T, Kataoka H. Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma. Anticancer Res (2007) 27:3685–92 - PubMed

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Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates

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Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates

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