Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jul;35(22):5731-40.
doi: 10.1016/j.biomaterials.2014.04.003. Epub 2014 Apr 22.

Multilevel surface engineering of nanostructured TiO2 on carbon-fiber-reinforced polyetheretherketone

Tao Lu  1 , Xuanyong Liu  2 , Shi Qian  1 , Huiliang Cao  1 , Yuqin Qiao  1 , Yongfeng Mei  3 , Paul K Chu  4 , Chuanxian Ding  1
Affiliations

Multilevel surface engineering of nanostructured TiO2 on carbon-fiber-reinforced polyetheretherketone

Tao Lu et al. Biomaterials. 2014 Jul.

Abstract

As an implantable material, carbon-fiber-reinforced polyetheretherketone (CFRPEEK) possesses an adjustable elastic modulus similar to that of cortical bone and is a prime candidate to replace metallic surgical implants. However, the bioinertness and poor osteogenic properties of CFRPEEK limit its clinical application as orthopedic implants. In this work, titanium ions are introduced energetically into CFRPEEK by plasma immersion ion implantation (PIII). Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) reveal the formation of nanopores with the side wall and bottom embedded with ∼20 nm TiO2 nanoparticles on the CFRPEEK surface. Nanoindentation measurements confirm the stability and improved elastic resistance of the structured surfaces. In vitro cell adhesion, viability assay, and real-time PCR analyses disclose enhanced adhesion, proliferation, and osteo-differentiation of rat bone mesenchymal stem cells (bMSCs). The multilevel structures on CFRPEEK also exhibit partial antibacterial activity to Staphylococcus aureus and Escherichia coli. Our results indicate that a surface with multifunctional biological properties can be produced by multilevel surface engineering and application of CFRPEEK to orthopedic and dental implants can be broadened and expedited based on this scheme.

Keywords: Antibacterial activity; Carbon-fiber-reinforced polyetheretherketone; Nanopores; Osteogenic activity; Plasma immersion ion implantation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources