IAPs, regulators of innate immunity and inflammation

doi:10.1016/j.semcdb.2014.03.035

Review

. 2015 Mar:39:106-14.

doi: 10.1016/j.semcdb.2014.03.035. Epub 2014 Apr 6.

IAPs, regulators of innate immunity and inflammation

Yann Estornes¹, Mathieu J M Bertrand²

Affiliations

¹ Inflammation Research Center, VIB, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium.
² Inflammation Research Center, VIB, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium. Electronic address: Mathieu.Bertrand@irc.vib-UGent.be.

PMID: 24718315
DOI: 10.1016/j.semcdb.2014.03.035

Review

IAPs, regulators of innate immunity and inflammation

Yann Estornes et al. Semin Cell Dev Biol. 2015 Mar.

. 2015 Mar:39:106-14.

doi: 10.1016/j.semcdb.2014.03.035. Epub 2014 Apr 6.

Authors

Yann Estornes¹, Mathieu J M Bertrand²

Affiliations

¹ Inflammation Research Center, VIB, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium.
² Inflammation Research Center, VIB, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium. Electronic address: Mathieu.Bertrand@irc.vib-UGent.be.

PMID: 24718315
DOI: 10.1016/j.semcdb.2014.03.035

Abstract

As indicated by their name, members of the Inhibitor of APoptosis (IAP) family were first believed to be functionally restricted to apoptosis inhibition. It is now clear that IAPs have a much wider spectrum of action, and recent studies even suggest that some of its members primarily regulate inflammatory responses. Inflammation, the first response of the immune system to infection or tissue injury, is highly regulated by ubiquitylation - a posttranslational modification of proteins with various consequences. In this review, we focus on the recently reported functions of XIAP, cIAP1 and cIAP2 as ubiquitin ligases regulating innate immunity and inflammation.

Keywords: IAP; NOD; RIG-I; TLR; TNF.

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IAPs, regulators of innate immunity and inflammation

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IAPs, regulators of innate immunity and inflammation

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