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. 1989 Jun;11(3):248-54.
doi: 10.1097/00000372-198906000-00009.

Lack of host cellular immune response in eruptive molluscum contagiosum

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Lack of host cellular immune response in eruptive molluscum contagiosum

M C Heng et al. Am J Dermatopathol. 1989 Jun.

Abstract

A lack of cellular immunity on the part of the host has been incriminated as the cause of the persistence of the cutaneous lesions of molluscum contagiosum. We present a patient in the eruptive phase of the disease, confirming the absence of T-lymphocyte and natural killer cell subsets in the base of these typical lesions, using a panel of monoclonal antibodies. We also report the observation of lipid material ultrastructurally (confirmed by osmium staining on fresh-frozen tissue), as well as cross-reactivity immunocytochemically of the antigens on these molluscum bodies with antigens normally present on macrophages, as defined by DAKO-macrophage monoclonal antibodies. We have considered the possible role of these findings in the lack of host cellular responsiveness in the eruptive phase of the disease.

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