Review
doi: 10.1016/j.ceb.2014.03.003.
Epub 2014 Mar 30.
Mechanisms and dynamics of nuclear lamina-genome interactions
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- PMID: 24694724
- DOI: 10.1016/j.ceb.2014.03.003
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Review
Mechanisms and dynamics of nuclear lamina-genome interactions
Curr Opin Cell Biol.
2014 Jun.
Abstract
The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization and gene expression. Both DNA sequences and histone modifications are important for NL tethering of the genomic DNA. These interactions are dynamic in individual cells and can change during differentiation and development. Evidence is accumulating that the NL contributes to the repression of transcription. Advances in mapping, genome-editing and microscopy techniques are increasing our understanding of the molecular mechanisms involved in NL-genome interactions.
Copyright © 2014 Elsevier Ltd. All rights reserved.
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