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doi: 10.1016/j.ccr.2014.02.022.
Leukemia propagating cells Akt up
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- PMID: 24651006
- DOI: 10.1016/j.ccr.2014.02.022
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Leukemia propagating cells Akt up
Cancer Cell.
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Free article
Abstract
Individual cancer cells can exhibit striking differences in tumorigenic potential following experimental transplantation, but the molecular pathways that regulate this activity remain poorly understood. In this issue of Cancer Cell, Blackburn and colleagues report that Akt signaling regulates both leukemia-propagating potential and proliferation rate via distinct pathways in T-ALL.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.Cancer Cell. 2014 Mar 17;25(3):366-78. doi: 10.1016/j.ccr.2014.01.032. Epub 2014 Mar 6. Cancer Cell. 2014. PMID: 24613413 Free PMC article.
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