doi: 10.1002/eji.1830181122.
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
Affiliations
- PMID: 2462501
- DOI: 10.1002/eji.1830181122
Item in Clipboard
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
Eur J Immunol.
1988 Nov.
Abstract
High levels of interleukin 6 (IL 6/B cell stimulatory factor-2) were detected in synovial fluids from the joints of patients with active rheumatoid arthritis (RA). The cells found in freshly isolated synovial fluid constitutively expressed IL 6 mRNA. The synovial tissues obtained by joint biopsy were also found to produce IL 6 in vitro. Immunohistochemical analysis demonstrated that CD2+ T cells as well as CD20+ blastoid B cells in the synovial tissues produce IL 6. The data indicate that IL 6 is generated constitutively in RA and its overproduction may explain the local as well as the generalized symptoms of RA, since IL 6 can function as B cell growth and differentiation factor as well as hepatocyte-stimulating factor.
Similar articles
-
Functional analysis of rheumatoid factor-producing B cells from the synovial fluid of rheumatoid arthritis patients.Arthritis Rheum. 1998 Dec;41(12):2211-20. doi: 10.1002/1529-0131(199812)41:12<2211::AID-ART17>3.0.CO;2-O. Arthritis Rheum. 1998. PMID: 9870878
-
Interleukin (IL)-23 p19 expression induced by IL-1beta in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kappaB and AP-1 dependent pathway.Rheumatology (Oxford). 2007 Aug;46(8):1266-73. doi: 10.1093/rheumatology/kem055. Epub 2007 Jun 14. Rheumatology (Oxford). 2007. PMID: 17569750
-
Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis.Scand J Immunol. 2006 Nov;64(5):515-22. doi: 10.1111/j.1365-3083.2006.01795.x. Scand J Immunol. 2006. PMID: 17032244
-
B lymphocyte function in patients with rheumatoid arthritis: impact of regulatory T lymphocytes and macrophages--modulation by antirheumatic drugs.Dan Med Bull. 1988 Apr;35(2):140-57. Dan Med Bull. 1988. PMID: 3282810 Review.
-
Interleukin-6: discovery of a pleiotropic cytokine.Arthritis Res Ther. 2006;8 Suppl 2(Suppl 2):S2. doi: 10.1186/ar1916. Epub 2006 Jul 28. Arthritis Res Ther. 2006. PMID: 16899106 Free PMC article. Review.
Cited by
-
Production and modulation of interleukin 6 synthesis by synoviocytes derived from patients with arthritic disease.Ann Rheum Dis. 1992 Feb;51(2):198-202. doi: 10.1136/ard.51.2.198. Ann Rheum Dis. 1992. PMID: 1550404 Free PMC article.
-
Role of lymphotoxin in expression of interleukin 6 in human fibroblasts. Stimulation and regulation.J Clin Invest. 1990 Jan;85(1):121-9. doi: 10.1172/JCI114401. J Clin Invest. 1990. PMID: 1688564 Free PMC article.
-
Vascular endothelium, cytokines, and the pathogenesis of inflammatory synovitis.Ann Rheum Dis. 1991 Nov;50(11):828-32. doi: 10.1136/ard.50.11.828. Ann Rheum Dis. 1991. PMID: 1772302 Free PMC article. Review. No abstract available.
-
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.J Exp Med. 2006 Jun 12;203(6):1459-70. doi: 10.1084/jem.20052187. Epub 2006 May 22. J Exp Med. 2006. PMID: 16717113 Free PMC article.
-
The potential roles of JAK/STAT signaling in the progression of osteoarthritis.Front Endocrinol (Lausanne). 2022 Nov 24;13:1069057. doi: 10.3389/fendo.2022.1069057. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36506076 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
