Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar 5;9(3):e90663.
doi: 10.1371/journal.pone.0090663. eCollection 2014.

Relation of leukocytes and its subsets counts with the severity of stable coronary artery disease in patients with diabetic mellitus

Li-Feng Hong  1 , Xiao-Lin Li  2 , Song-Hui Luo  3 , Yuan-Lin Guo  2 , Jun Liu  2 , Cheng-Gang Zhu  2 , Ping Qing  2 , Rui-Xia Xu  2 , Na-Qiong Wu  2 , Li-Xin Jiang  2 , Jian-Jun Li  2
Affiliations

Relation of leukocytes and its subsets counts with the severity of stable coronary artery disease in patients with diabetic mellitus

Li-Feng Hong et al. PLoS One. .

Abstract

Background: Both coronary artery disease (CAD) and diabetes mellitus (DM) are associated with inflammation. However, whether and which leukocytes can predict the presence and extent of CAD in patients with DM has not been investigated. The aim of the present study was to examine the association of leukocyte and its subsets counts with the severity of CAD in patients with DM.

Methods and findings: Three hundred and seventy-three diabetic patients who were scheduled for coronary angiography due to typical stable angina pectoris were enrolled in this study. They were classified into the three groups according to tertiles of Gensini score (GS, low group <8, n=143; intermediate group 8~28, n=109; high group >28, n=121). The relationship between the leukocyte and its subsets counts with the severity of CAD were evaluated. The data indicated that there were significant correlations between leukocyte and neutrophil counts with GS (r=0.154 and 0.156, respectively, all P<0.003 for Pearson's correlation). Similarly, area under the receivers operating characteristic curve of leukocyte and neutrophil counts were 0.61 and 0.60 respectively (95%CI: 0.55-0.67, all P=0.001) for predicting high GS. Multivariate logistic regression analysis demonstrated that leukocyte count was an independent predictor for high GS patients with DM (OR=1.20, 95%CI 1.03-1.39, P=0.023) after adjusting for conventional risk factors of CAD.

Conclusions: Compared with its subsets, leukocyte count appeared to be an independent predictor for the severity of CAD and the optimal cut-off value for predicting high GS (>28 points) was 5.0 × 10(9) cells/L in diabetic patients.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. The results of leukocyte (A), neutrophil (B), lymphocyte (C) and monocyte (D) counts according to the Gensini Score.
Figure 2
Figure 2. The results of receiver operating characteristic (ROC) curve analysis for the predictive power of the leukocyte counts and the Gensini score.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Zairis MN, Adamopoulou EN, Manousakis SJ, Lyras AG, Bibis GP, et al. (2007) The impact of hs C-reactive protein and other inflammatory biomarkers on long-term cardiovascular mortality in patients with acute coronary syndromes. Atherosclerosis 194: 397–402. - PubMed
    1. Damman P, Beijk MA, Kuijt WJ, Verouden NJ, van Geloven N, et al. (2011) Multiple biomarkers at admission significantly improve the prediction of mortality in patients undergoing primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. J Am Coll Cardiol 57: 29–36. - PubMed
    1. Sinning JM, Bickel C, Messow CM, Schnabel R, Lubos E, et al. (2006) Impact of C-reactive protein and fibrinogen on cardiovascular prognosis in patients with stable angina pectoris: the AtheroGene study. Eur Heart J 27: 2962–2968. - PubMed
    1. Kaptoge S, Di Angelantonio E, Lowe G, Pepys MB, Thompson SG, et al. (2010) C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet 375: 132–140. - PMC - PubMed
    1. Ziakas A, Gavrilidis S, Giannoglou G, Souliou E, Koskinas K, et al. (2009) Kinetics and prognostic value of inflammatory-sensitive protein, IL-6, and white blood cell levels in patients undergoing coronary stent implantation. Med Sci Monit 15: CR177–184. - PubMed

Publication types

Grants and funding

This article was partly supported by National Natural Scientific Foundation (81070171, 81241121), Specialized Research Fund for the Doctoral Program of Higher Education of China (20111106110013), Capital Special Foundation of Clinical Application Research (Z121107001012015), Capital Health Development Fund (2011400302), and Beijing Natural Science Foundation (7131014) awarded to Dr. Jian-Jun Li, MD, PhD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.