MERS: emergence of a novel human coronavirus

doi:10.1016/j.coviro.2014.01.010

Review

. 2014 Apr:5:58-62.

doi: 10.1016/j.coviro.2014.01.010. Epub 2014 Feb 28.

MERS: emergence of a novel human coronavirus

V Stalin Raj¹, Albert D M E Osterhaus¹, Ron A M Fouchier¹, Bart L Haagmans²

Affiliations

¹ Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
² Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: b.haagmans@erasmusmc.nl.

PMID: 24584035
PMCID: PMC4028407
DOI: 10.1016/j.coviro.2014.01.010

Review

MERS: emergence of a novel human coronavirus

V Stalin Raj et al. Curr Opin Virol. 2014 Apr.

. 2014 Apr:5:58-62.

doi: 10.1016/j.coviro.2014.01.010. Epub 2014 Feb 28.

Authors

V Stalin Raj¹, Albert D M E Osterhaus¹, Ron A M Fouchier¹, Bart L Haagmans²

Affiliations

¹ Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
² Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: b.haagmans@erasmusmc.nl.

PMID: 24584035
PMCID: PMC4028407
DOI: 10.1016/j.coviro.2014.01.010

Abstract

A novel coronavirus (CoV) that causes a severe lower respiratory tract infection in humans, emerged in the Middle East region in 2012. This virus, named Middle East respiratory syndrome (MERS)-CoV, is phylogenetically related to bat CoVs, but other animal species like dromedary camels may potentially act as intermediate hosts by spreading the virus to humans. Although human to human transmission has been demonstrated, analysis of human MERS clusters indicated that chains of transmission were not self-sustaining, especially when infection control was implemented. Thus, timely identification of new MERS cases followed by their quarantine, combined with measures to limit spread of the virus from the (intermediate) host to humans, may be crucial in controlling the outbreak of this emerging CoV.

PubMed Disclaimer

Figures

**Figure 1**
Schematic diagram of the potential zoonotic transmission of MERS-CoV.

See this image and copyright information in PMC

Cited by

Scaling the Need, Benefits, and Risks Associated with COVID-19 Acute and Postacute Care Rehabilitation: A Review.
Shah SZA, Nasb M, Lu M, Huang L, Wang Y, Chen H. Shah SZA, et al. Rehabil Res Pract. 2020 Aug 26;2020:3642143. doi: 10.1155/2020/3642143. eCollection 2020. Rehabil Res Pract. 2020. PMID: 32908705 Free PMC article.
Viral Emerging Diseases: Challenges in Developing Vaccination Strategies.
Trovato M, Sartorius R, D'Apice L, Manco R, De Berardinis P. Trovato M, et al. Front Immunol. 2020 Sep 3;11:2130. doi: 10.3389/fimmu.2020.02130. eCollection 2020. Front Immunol. 2020. PMID: 33013898 Free PMC article. Review.
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?
Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Dubé M, Talbot PJ. Desforges M, et al. Viruses. 2019 Dec 20;12(1):14. doi: 10.3390/v12010014. Viruses. 2019. PMID: 31861926 Free PMC article. Review.
Plant Extracts and SARS-CoV-2: Research and Applications.
Heleno SA, Carocho M, Reis FS, Pires TCSP, Pintado M, Ferreira ICFR, Barros L. Heleno SA, et al. Life (Basel). 2023 Jan 31;13(2):386. doi: 10.3390/life13020386. Life (Basel). 2023. PMID: 36836744 Free PMC article. Review.
Genomic epidemiology of SARS-CoV-2 from Uttar Pradesh, India.
Misra G, Manzoor A, Chopra M, Upadhyay A, Katiyar A, Bhushan B, Anvikar A. Misra G, et al. Sci Rep. 2023 Sep 8;13(1):14847. doi: 10.1038/s41598-023-42065-6. Sci Rep. 2023. PMID: 37684328 Free PMC article.

See all "Cited by" articles

References

1. Ksiazek T.G., Erdman D., Goldsmith C.S., Zaki S.R., Peret T., Emery S., Tong S., Urbani C., Comer J.A., Lim W. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348:1953–1966. - PubMed
1. Peiris J.S., Lai S.T., Poon L.L., Guan Y., Yam L.Y., Lim W., Nicholls J., Yee W.K., Yan W.W., Cheung M.T. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319–1325. - PMC - PubMed
1. Guan Y., Zheng B.J., He Y.Q., Liu X.L., Zhuang Z.X., Cheung C.L., Luo S.W., Li P.H., Zhang L.J., Guan Y.J. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science. 2003;302:276–278. - PubMed
1. Lau S.K., Woo P.C., Li K.S., Huang Y., Tsoi H.W., Wong B.H., Wong S.S., Leung S.Y., Chan K.H., Yuen K.Y. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci USA. 2005;102:14040–14045. - PMC - PubMed
1. Perlman S., Netland J. Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol. 2009;7:439–450. - PMC - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

HHSN266200700010C/AI/NIAID NIH HHS/United States

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Ksiazek T.G., Erdman D., Goldsmith C.S., Zaki S.R., Peret T., Emery S., Tong S., Urbani C., Comer J.A., Lim W. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348:1953–1966. - PubMed

[2] Ksiazek T.G., Erdman D., Goldsmith C.S., Zaki S.R., Peret T., Emery S., Tong S., Urbani C., Comer J.A., Lim W. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348:1953–1966. - PubMed

[3] Peiris J.S., Lai S.T., Poon L.L., Guan Y., Yam L.Y., Lim W., Nicholls J., Yee W.K., Yan W.W., Cheung M.T. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319–1325. - PMC - PubMed

[4] Peiris J.S., Lai S.T., Poon L.L., Guan Y., Yam L.Y., Lim W., Nicholls J., Yee W.K., Yan W.W., Cheung M.T. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319–1325. - PMC - PubMed

[5] Guan Y., Zheng B.J., He Y.Q., Liu X.L., Zhuang Z.X., Cheung C.L., Luo S.W., Li P.H., Zhang L.J., Guan Y.J. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science. 2003;302:276–278. - PubMed

[6] Guan Y., Zheng B.J., He Y.Q., Liu X.L., Zhuang Z.X., Cheung C.L., Luo S.W., Li P.H., Zhang L.J., Guan Y.J. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science. 2003;302:276–278. - PubMed

[7] Lau S.K., Woo P.C., Li K.S., Huang Y., Tsoi H.W., Wong B.H., Wong S.S., Leung S.Y., Chan K.H., Yuen K.Y. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci USA. 2005;102:14040–14045. - PMC - PubMed

[8] Lau S.K., Woo P.C., Li K.S., Huang Y., Tsoi H.W., Wong B.H., Wong S.S., Leung S.Y., Chan K.H., Yuen K.Y. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci USA. 2005;102:14040–14045. - PMC - PubMed

[9] Perlman S., Netland J. Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol. 2009;7:439–450. - PMC - PubMed

[10] Perlman S., Netland J. Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol. 2009;7:439–450. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

MERS: emergence of a novel human coronavirus

Affiliations

MERS: emergence of a novel human coronavirus

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical