How T cells lose their touch

doi:10.1016/j.immuni.2014.02.001

Comment

. 2014 Feb 20;40(2):169-71.

doi: 10.1016/j.immuni.2014.02.001.

How T cells lose their touch

Michael L Dustin¹

Affiliations

Affiliation

¹ Kennedy Institute of Rheumatology, NDORMS, The University of Oxford, Headington, Oxford OX3 7FY, UK; Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA. Electronic address: michael.dustin@kennedy.ox.ac.uk.

PMID: 24560192
PMCID: PMC5615101
DOI: 10.1016/j.immuni.2014.02.001

Comment

How T cells lose their touch

Michael L Dustin. Immunity. 2014.

. 2014 Feb 20;40(2):169-71.

doi: 10.1016/j.immuni.2014.02.001.

Author

Michael L Dustin¹

Affiliation

¹ Kennedy Institute of Rheumatology, NDORMS, The University of Oxford, Headington, Oxford OX3 7FY, UK; Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA. Electronic address: michael.dustin@kennedy.ox.ac.uk.

PMID: 24560192
PMCID: PMC5615101
DOI: 10.1016/j.immuni.2014.02.001

Abstract

T cells are among the most sensitive of cells, but in this issue of Immunity, Honda et al. (2014) demonstrate that effector T cells must lose their touch within hours to protect the host from immunopathology.

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Comment on

Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues.
Honda T, Egen JG, Lämmermann T, Kastenmüller W, Torabi-Parizi P, Germain RN. Honda T, et al. Immunity. 2014 Feb 20;40(2):235-247. doi: 10.1016/j.immuni.2013.11.017. Epub 2014 Jan 16. Immunity. 2014. PMID: 24440150 Free PMC article.

References

1. Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007;27:111–122. - PMC - PubMed
1. Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009;10:1185–1192. - PMC - PubMed
1. Honda T, Egen JG, Lammermann T, Kastenmuller W, Torabi-Parizi P, Germain RN. Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues. Immunity 2014 - PMC - PubMed
1. Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM. T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol. 2006;7:247–255. - PubMed
1. Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 2009;457:191–195. - PMC - PubMed

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[1] Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007;27:111–122. - PMC - PubMed

[2] Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007;27:111–122. - PMC - PubMed

[3] Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009;10:1185–1192. - PMC - PubMed

[4] Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009;10:1185–1192. - PMC - PubMed

[5] Honda T, Egen JG, Lammermann T, Kastenmuller W, Torabi-Parizi P, Germain RN. Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues. Immunity 2014 - PMC - PubMed

[6] Honda T, Egen JG, Lammermann T, Kastenmuller W, Torabi-Parizi P, Germain RN. Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues. Immunity 2014 - PMC - PubMed

[7] Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM. T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol. 2006;7:247–255. - PubMed

[8] Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM. T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol. 2006;7:247–255. - PubMed

[9] Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 2009;457:191–195. - PMC - PubMed

[10] Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 2009;457:191–195. - PMC - PubMed

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How T cells lose their touch

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How T cells lose their touch

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