Radiation redux: reserve intestinal stem cells miss the call to duty

doi:10.1016/j.stem.2014.01.015

Comment

. 2014 Feb 6;14(2):135-6.

doi: 10.1016/j.stem.2014.01.015.

Radiation redux: reserve intestinal stem cells miss the call to duty

Ramesh A Shivdasani¹

Affiliations

Affiliation

¹ Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address: ramesh_shivdasani@dfci.harvard.edu.

PMID: 24506878
PMCID: PMC3955177
DOI: 10.1016/j.stem.2014.01.015

Comment

Radiation redux: reserve intestinal stem cells miss the call to duty

Ramesh A Shivdasani. Cell Stem Cell. 2014.

. 2014 Feb 6;14(2):135-6.

doi: 10.1016/j.stem.2014.01.015.

Author

Ramesh A Shivdasani¹

Affiliation

¹ Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address: ramesh_shivdasani@dfci.harvard.edu.

PMID: 24506878
PMCID: PMC3955177
DOI: 10.1016/j.stem.2014.01.015

Abstract

Distinct stem cell populations in intestinal crypts mediate tissue homeostasis and responses to epithelial damage such as radiation. Now in Cell Stem Cell, Metcalfe et al. (2014) demonstrate that homeostatic, proliferative Lrg5(+) cells are necessary to regenerate the epithelium after radiation, whereas quiescent Lgr5(-) reserve stem cells are surprisingly radiosensitive.

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Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration.
Metcalfe C, Kljavin NM, Ybarra R, de Sauvage FJ. Metcalfe C, et al. Cell Stem Cell. 2014 Feb 6;14(2):149-59. doi: 10.1016/j.stem.2013.11.008. Epub 2013 Dec 12. Cell Stem Cell. 2014. PMID: 24332836

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References

1. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003–1007. - PubMed
1. Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457:608–611. - PubMed
1. Barker N, van Oudenaarden A, Clevers H. Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell. 2012;11:452–460. - PubMed
1. Buczacki SJ, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, Kemp R, Winton DJ. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature. 2013;495:65–69. - PubMed
1. Kim TH, Li F, I F-N, Ho L-L, Luyten A, Nalapareddy K, Long H, Verzi M, Shivdasani RA. Broadly permissive intestnal chromatin underlies lateral inhibition and cell pasticity. Nature. 2014 doi:10.1038/nature12903. - PMC - PubMed

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[1] Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003–1007. - PubMed

[2] Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003–1007. - PubMed

[3] Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457:608–611. - PubMed

[4] Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457:608–611. - PubMed

[5] Barker N, van Oudenaarden A, Clevers H. Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell. 2012;11:452–460. - PubMed

[6] Barker N, van Oudenaarden A, Clevers H. Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell. 2012;11:452–460. - PubMed

[7] Buczacki SJ, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, Kemp R, Winton DJ. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature. 2013;495:65–69. - PubMed

[8] Buczacki SJ, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, Kemp R, Winton DJ. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature. 2013;495:65–69. - PubMed

[9] Kim TH, Li F, I F-N, Ho L-L, Luyten A, Nalapareddy K, Long H, Verzi M, Shivdasani RA. Broadly permissive intestnal chromatin underlies lateral inhibition and cell pasticity. Nature. 2014 doi:10.1038/nature12903. - PMC - PubMed

[10] Kim TH, Li F, I F-N, Ho L-L, Luyten A, Nalapareddy K, Long H, Verzi M, Shivdasani RA. Broadly permissive intestnal chromatin underlies lateral inhibition and cell pasticity. Nature. 2014 doi:10.1038/nature12903. - PMC - PubMed

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Radiation redux: reserve intestinal stem cells miss the call to duty

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Radiation redux: reserve intestinal stem cells miss the call to duty

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