Analysis of early strains of the norovirus pandemic variant GII.4 Sydney 2012 identifies mutations in adaptive sites of the capsid protein
- PMID: 24503099
- DOI: 10.1016/j.virol.2013.12.007
Analysis of early strains of the norovirus pandemic variant GII.4 Sydney 2012 identifies mutations in adaptive sites of the capsid protein
Abstract
Global surveillance for norovirus identified in 2012 the emergence of a novel pandemic GII.4 variant, termed Sydney 2012. In Italy, the novel pandemic variant was identified as early as November 2011 but became predominant only in the winter season 2012-2013. Upon sequencing and comparison with strains of global origin, the early Sydney 2012 strains were found to differ from those spreading in 2012-2013 in the capsid (ORF2) putative epitopes B, C and D, segregating into a distinct phylogenetic clade. At least three residues (333, 340 and 393, in epitopes B, C and D, respectively) of the VP1 varied among Sydney 2012 strains of different clades. These findings suggest that the spread of the pandemic variant in Italy during the winter season 2012-2013 was due to the introduction of strains distinct from those circulating at low frequency in the former winter season and that similar strains were also circulating elsewhere worldwide.
Keywords: Capsid protein VP1 epitopes; Evolution; GII.4; Italy; Norovirus; Sydney 2012 variant.
Copyright © 2013 Elsevier Inc. All rights reserved.
Similar articles
-
Genetic Analysis of Norovirus GII.4 Variant Strains Detected in Outbreaks of Gastroenteritis in Yokohama, Japan, from the 2006-2007 to the 2013-2014 Seasons.PLoS One. 2015 Nov 6;10(11):e0142568. doi: 10.1371/journal.pone.0142568. eCollection 2015. PLoS One. 2015. PMID: 26544040 Free PMC article.
-
Molecular epidemiology of norovirus associated with gastroenteritis and emergence of norovirus GII.4 variant 2012 in Japanese pediatric patients.Infect Genet Evol. 2014 Apr;23:65-73. doi: 10.1016/j.meegid.2014.01.030. Epub 2014 Feb 4. Infect Genet Evol. 2014. PMID: 24508246
-
Emergence of novel recombinant GII.P16_GII.2 and GII. P16_GII.4 Sydney 2012 norovirus strains in Italy, winter 2016/2017.New Microbiol. 2018 Jan;41(1):71-72. New Microbiol. 2018. PMID: 29505067
-
Characterization of GII.4 noroviruses circulating among children with acute gastroenteritis in Pune, India: 2005-2013.Infect Genet Evol. 2016 Jan;37:163-73. doi: 10.1016/j.meegid.2015.11.016. Epub 2015 Nov 27. Infect Genet Evol. 2016. PMID: 26611824
-
The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012.Virology. 2014 Feb;450-451:106-13. doi: 10.1016/j.virol.2013.12.005. Epub 2013 Dec 25. Virology. 2014. PMID: 24503072 Free PMC article.
Cited by
-
Molecular Evolution of GII.P31/GII.4_Sydney_2012 Norovirus over a Decade in a Clinic in Japan.Int J Mol Sci. 2024 Mar 23;25(7):3619. doi: 10.3390/ijms25073619. Int J Mol Sci. 2024. PMID: 38612429 Free PMC article.
-
Comparative genome analysis of a norovirus GII.4 strain GZ2013-L10 isolated from South China.Virus Genes. 2016 Feb;52(1):14-21. doi: 10.1007/s11262-015-1283-9. Epub 2016 Jan 4. Virus Genes. 2016. PMID: 26728079
-
Genetic Analysis of Norovirus GII.4 Variant Strains Detected in Outbreaks of Gastroenteritis in Yokohama, Japan, from the 2006-2007 to the 2013-2014 Seasons.PLoS One. 2015 Nov 6;10(11):e0142568. doi: 10.1371/journal.pone.0142568. eCollection 2015. PLoS One. 2015. PMID: 26544040 Free PMC article.
-
Epidemiology and molecular characteristics of norovirus GII.4 Sydney outbreaks in Taiwan, January 2012-December 2013.J Med Virol. 2015 Sep;87(9):1462-70. doi: 10.1002/jmv.24208. Epub 2015 May 6. J Med Virol. 2015. PMID: 25946552 Free PMC article.
-
Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity.Clin Vaccine Immunol. 2015 Feb;22(2):221-8. doi: 10.1128/CVI.00516-14. Epub 2014 Dec 24. Clin Vaccine Immunol. 2015. PMID: 25540269 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
