MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)

doi:10.1016/j.bbrc.2014.01.140

. 2014 Feb 28;445(1):151-6.

doi: 10.1016/j.bbrc.2014.01.140. Epub 2014 Jan 31.

MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)

Dachuang Liu¹, Tao Tao², Bin Xu², Shuqiu Chen², Chunhui Liu², Lei Zhang³, Kai Lu³, Yeqing Huang², Liang Jiang², Xiaowen Zhang³, Xiaoming Huang⁴, Lihua Zhang⁵, Conghui Han⁶, Ming Chen⁷

Affiliations

¹ Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Department of Urology, Xuzhou Central Hospital Affiliated with Southeast University, Xuzhou, Jiangsu Province 221009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
² Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
³ Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China.
⁴ Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
⁵ Department of Pathology, Zhongda Hospital Affiliated with Southeast University, Nanjing, Jiangsu Province 210009, China.
⁶ Department of Urology, Xuzhou Central Hospital Affiliated with Southeast University, Xuzhou, Jiangsu Province 221009, China.
⁷ Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China. Electronic address: mingchenseu@gmail.com.

PMID: 24491557
DOI: 10.1016/j.bbrc.2014.01.140

MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)

Dachuang Liu et al. Biochem Biophys Res Commun. 2014.

. 2014 Feb 28;445(1):151-6.

doi: 10.1016/j.bbrc.2014.01.140. Epub 2014 Jan 31.

Authors

Affiliations

¹ Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Department of Urology, Xuzhou Central Hospital Affiliated with Southeast University, Xuzhou, Jiangsu Province 221009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
² Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
³ Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China.
⁴ Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
⁵ Department of Pathology, Zhongda Hospital Affiliated with Southeast University, Nanjing, Jiangsu Province 210009, China.
⁶ Department of Urology, Xuzhou Central Hospital Affiliated with Southeast University, Xuzhou, Jiangsu Province 221009, China.
⁷ Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China. Electronic address: mingchenseu@gmail.com.

PMID: 24491557
DOI: 10.1016/j.bbrc.2014.01.140

Abstract

Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa.

Keywords: Bcl-xL; Castration-resistant prostate cancer (CRPC); STAT6; miR-361-5p.

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MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)

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MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)

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