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. 2014 Jan 8:7:101-10.
doi: 10.2147/OTT.S51835. eCollection 2014.

Effect of onion flavonoids on colorectal cancer with hyperlipidemia: an in vivo study

Yongshan He  1 , Heiying Jin  1 , Wei Gong  2 , Chunxia Zhang  1 , Acheng Zhou  1
Affiliations

Effect of onion flavonoids on colorectal cancer with hyperlipidemia: an in vivo study

Yongshan He et al. Onco Targets Ther. .

Abstract

Objectives: This study aims to find the effect of onion's extraction on the colorectal cancer with hyperlipidemia.

Method: We established a hyperlipidemia-subcutaneously heterotopic colorectal cancer orthotopic transplant model and fed mice a high fat diet and performing transplantation. Animal models were treated with capecitabine and/or simvastatin and low-, middle-, high- dose of onion's extraction and both tumor growth rate and blood lipid levels were monitored.

Results: We found that colorectal cancer in onion's extraction groups was significantly inhibited, and the effect of high dose of onion's extraction was equivalent to capecitabine. Onion's extraction effectively decreased levels of apoB and TC.

Conclusion: Our study established a hyperlipidemia colon tumor model involving subcutaneous colon translocation and orthotopic transplantation, this model was an ideal research model for mutual influence of hyperlipidemia and colorectal cancer. Onion's extraction could inhibit the proliferation of colorectal cancer; the function of the high-dose of onion's extraction was fairly to capecitabine, which provided a new direction in protecting and treating colorectal cancer.

Keywords: capecitabine; colorectal cancer; hyperlipidemia; onion flavonoids; simvastatin.

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Figures

Figure 1
Figure 1
Tumor volume after treatment. Mice in the FAT-SAL group had the fastest tumor-growth rate, and this rate was significantly faster than the tumor-growth rate in other groups except the FAT-SIM group. Additional analysis showed that the tumor-growth rates in mice in the FAT-SIM group, while markedly lower than those in the FAT-SAL group, was higher than those in the SDT-CAP, FAT-CAP, FAT-SIM, FAT-SIM+CAP, FAT-ONION-L, FAT-ONION-M, and FAT-ONION-H groups. The tumor-growth rates in the SDT-CAP group were lower than those in the FAT-ONION-L and FAT-ONION-M groups and higher than those in the FAT-CAP, FAT-SIM+CAP, and FAT-ONION-H groups (P>0.05). Tumors in mice in the FAT-SIM+CAP group displayed the slowest growth rate; this growth rate was slightly lower than the growth rate in the FAT-ONION-H and FAT-CAP groups (P>0.05), and remarkably lower than that in the FAT-ONION-L and FAT-ONION-M groups (P<0.05). No significant difference was observed among the FAT-ONION-L, FAT-ONION-M, and FAT-ONION-H groups. However, the fastest and slowest growth rates were present in the FAT-ONION-L group and FAT-ONION-H group, respectively. Abbreviations: SDT-CAP, standard diet with capecitabine; FAT-SAL, fat food with saline; FAT-CAP, fat food with capecitabine; FAT-SIM, fat food with simvastatin; FAT-SIM+CAP, fat food with simvastatin and capecitabine; FAT-ONION-L, fat diet and low-dose onion flavonoids; FAT-ONION-M, fat diet and middle-dose onion flavonoids; FAT-ONION-H, fat diet and high-dose onion flavonoids; W, week.
Figure 2
Figure 2
Tumor growth-rate curves. Tumor growth-rate curves are similar to tumor-proliferation curves. Abbreviations: SDT-CAP, standard diet with capecitabine; FAT-SAL, fat food with saline; FAT-CAP, fat food with capecitabine; FAT-SIM, fat food with simvastatin; FAT-SIM+CAP, fat food with simvastatin and capecitabine; FAT-ONION-L, fat diet and low-dose onion flavonoids; FAT-ONION-M, fat diet and middle-dose onion flavonoids; FAT-ONION-H, fat diet and high-dose onion flavonoids; W, week.
Figure 3
Figure 3
Tumor weight after death. Tumors in the FAT-SAL group showed the most growth, and the growth rate in the FAT-SAL group was significantly faster than that in the SDT-CAP, FAT-CAP, FAT-SIM+CAP, FAT-ONION-L, FAT-ONION-M, and FAT-ONION-H groups. No significant difference was observed between the FAT-SIM group and the FAT-SAL group. The growth rate in the FAT-SIM group was only slightly higher than that in the SDT-CAP and FAT-ONION-L groups, but markedly higher than that in the FAT-CAP, FAT-SIM+CAP, FAT-ONION-M, and FAT-ONION-H groups. The lightest tumor weight was in the FAT-CAP group, and the tumor weight in the FAT-CAP group was lower than that in the FAT-ONION-L (P<0.05), FAT-SIM+CAP (P>0.05), FAT-ONION-M (P>0.05), and FAT-ONION-H (P>0.05) groups. Among the FAT-ONION-L, FAT-ONION-M, and FAT-ONION-H groups, mice in FAT-ONION-L presented the maximum tumor weight, and mice in FAT-ONION-H showed the lightest tumor weight. However, no significant difference was observed among these three groups. Abbreviations: SDT-CAP, standard diet with capecitabine; FAT-SAL, fat food with saline; FAT-CAP, fat food with capecitabine; FAT-SIM, fat food with simvastatin; FAT-SIM+CAP, fat food with simvastatin and capecitabine; FAT-ONION-L, fat diet and low-dose onion flavonoids; FAT-ONION-M, fat diet and middle-dose onion flavonoids; FAT-ONION-H, fat diet and high-dose onion flavonoids.
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