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. 2014 Mar;12(1):76-89.
doi: 10.1007/s11938-013-0005-4.

Current and Future Status of Therapeutic Drug Monitoring in the Treatment of IBD

Reena Khanna  1 , Brian G Feagan
Affiliations

Current and Future Status of Therapeutic Drug Monitoring in the Treatment of IBD

Reena Khanna et al. Curr Treat Options Gastroenterol. 2014 Mar.

Abstract

Although tumor necrosis factor (TNF)-antagonists are highly effective agents for the treatment of inflammatory bowel diseases (IBD), up to 40 % of patients ultimately lose response. As a result of the limited availability of treatment options, empiric dose escalation or switching of TNF-antagonists have evolved as strategies to regain response. Recently, therapeutic drug monitoring (TDM) (measurement of serum drug and antidrug antibody concentrations) has emerged to facilitate informed decision-making in patients with secondary loss of response to a TNF-antagonist. The evidence supporting the use of TDM in clinical practice and future applications of this approach will be discussed.

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