Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:236085.
doi: 10.1155/2013/236085. Epub 2013 Nov 25.

Acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 Peptide changes related to the body mass index

Yusuf Ozkan  1 , Esra Suay Timurkan  1 , Suleyman Aydin  2 , Ibrahim Sahin  3 , Mustafa Timurkan  1 , Cihan Citil  4 , Mehmet Kalayci  2 , Musa Yilmaz  2 , Aziz Aksoy  5 , Zekiye Catak  2
Affiliations

Acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 Peptide changes related to the body mass index

Yusuf Ozkan et al. Int J Endocrinol. 2013.

Abstract

This study examines the levels of acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index (BMI). The subjects were allocated to 5 groups depending on their BMIs as follows: Group I (BMI <18.5 kg/m(2)); Group II (BMI 18.5-24.9 kg/m(2)); Group III (BMI 25-29.9 kg/m(2)); Group IV (BMI 30-39.9 kg/m(2)); Group V (BMI >40 kg/m(2)). Serum acylated and desacylated ghrelin, preptin, and leptin levels were measured by the enzyme-linked immunosorbent assay (ELISA) and nesfatin-1 was measured by the enzyme immunoassay (EIA). Desacylated ghrelin levels showed a gradual and statistically significant drop from Group I to Group V, while preptin and leptin levels exhibited a gradual and significant increase from Group I to Group IV. Serum nesfatin-1 levels gradually, but not significantly, increased from Group I to Group III and showed a significant decrease in Groups IV and V. In conclusion, leptin, preptin, and acylated ghrelin (AG) levels increased with higher BMI, whereas desacylated ghrelin (DAG) decreased and nesfatin-1 showed no clear relationship to BMI.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Serum acylated ghrelin levels in relation to BMIs. Group I: low-weight; Group II: normal-weight; Group III: overweight; Group IV: obese; Group V: morbidly obese. P < 0.005 for Group I versus Group IV and Group V.
Figure 2
Figure 2
Serum desacylated ghrelin levels in relation to BMIs. Group I: low-weight; Group II: normal-weight; Group III: overweight; Group IV: obese; Group V: morbidly obese. P < 0.005 for Group I versus Group II versus Group III versus Group IV and Group V.
Figure 3
Figure 3
Serum preptin levels in relation to BMIs. Group I: low-weight; Group II: normal-weight; Group III: overweight; Group IV: obese; Group V: morbidly obese. P < 0.005 for Group I versus Group II versus Group III versus Group IV and Group V.
Figure 4
Figure 4
Serum nesfatin-1 levels in relation to BMIs. Group I: low-weight; Group II: normal-weight; Group III: overweight; Group IV: obese; Group V: morbidly obese. P < 0.005 for Group I versus Group IV and Group V.
Figure 5
Figure 5
Serum leptin levels in relation to BMIs. Group I: low-weight; Group II: normal-weight; Group III: overweight; Group IV: obese; Group V: morbidly obese. P < 0.005 for Group I versus Group II versus Group III versus Group IV and Group V.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656–660. - PubMed
    1. Aydın S, Özkan Y, Çaylak E, Aydın S. Ghrelin and its biochemical functions. Journal of Medical Sciences. 2006;26(3):272–283.
    1. Majchrzak K, Szyszko K, Pawłowski KM, Motyl T, Król M. A role of ghrelin in cancerogenesis. Polish Journal of Veterinary Sciences. 2012;15(1):189–197. - PubMed
    1. Aydın S. Ghrelin Hormonunun Keşfi, Araştırmaları ve Klinik Uygulamaları. Turkish Journal of Biochemistry. 2007;32(2):76–89.
    1. Inhoff T, Wiedenmann B, Klapp BF, Mönnikes H, Kobelt P. Is desacyl ghrelin a modulator of food intake? Peptides. 2009;30(5):991–994. - PubMed

LinkOut - more resources