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Review
. 2014 Apr:115:92-115.
doi: 10.1016/j.pneurobio.2013.11.007. Epub 2013 Dec 12.

Cell based therapies for ischemic stroke: from basic science to bedside

Xinfeng Liu  1 , Ruidong Ye  2 , Tao Yan  3 , Shan Ping Yu  4 , Ling Wei  4 , Gelin Xu  2 , Xinying Fan  2 , Yongjun Jiang  2 , R Anne Stetler  5 , George Liu  6 , Jieli Chen  7
Affiliations
Review

Cell based therapies for ischemic stroke: from basic science to bedside

Xinfeng Liu et al. Prog Neurobiol. 2014 Apr.

Abstract

Cell therapy is emerging as a viable therapy to restore neurological function after stroke. Many types of stem/progenitor cells from different sources have been explored for their feasibility and efficacy for the treatment of stroke. Transplanted cells not only have the potential to replace the lost circuitry, but also produce growth and trophic factors, or stimulate the release of such factors from host brain cells, thereby enhancing endogenous brain repair processes. Although stem/progenitor cells have shown a promising role in ischemic stroke in experimental studies as well as initial clinical pilot studies, cellular therapy is still at an early stage in humans. Many critical issues need to be addressed including the therapeutic time window, cell type selection, delivery route, and in vivo monitoring of their migration pattern. This review attempts to provide a comprehensive synopsis of preclinical evidence and clinical experience of various donor cell types, their restorative mechanisms, delivery routes, imaging strategies, future prospects and challenges for translating cell therapies as a neurorestorative regimen in clinical applications.

Keywords: Cell-based therapies; Ischemic stroke; Neurorestoration; Stem cells.

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Conflict of interest statement

Conflict of interest

None declared.

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References

    1. Abe K, Yamashita T, Takizawa S, Kuroda S, Kinouchi H, Kawahara N. Stem cell therapy for cerebral ischemia: from basic science to clinical applications. Journal of Cerebral Blood Flow and Metabolism. 2012;32:1317–1331. - PMC - PubMed
    1. Adamczak J, Hoehn M. In vivo imaging of cell transplants in experimental ischemia. Progress in Brain Research. 2012;201:55–78. - PubMed
    1. Afzal MR, Haider H, Idris NM, Jiang S, Ahmed RP, Ashraf M. Preconditioning promotes survival and angiomyogenic potential of mesenchymal stem cells in the infarcted heart via NF-kappaB signaling. Antioxidants & Redox Signaling. 2010;12:693–702. - PMC - PubMed
    1. Aimone JB, Deng W, Gage FH. Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron. 2011;70:589–596. - PMC - PubMed
    1. Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH, 2nd, Salvesen GS, Connolly ES, Jr, Troy CM. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. Journal of Neuroscience. 2011;31:8894–8904. - PMC - PubMed

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