Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Feb;7(1):1-8.
doi: 10.1007/s12265-013-9520-x. Epub 2013 Dec 6.

Monocyte-platelets aggregates as cellular biomarker of endothelium-dependent coronary vasomotor dysfunction in patients with coronary artery disease

Luigi Di Serafino  1 , Jaydeep Sarma, Karen Dierickx, Ioannis Ntarladimas, Stylianos A Pyxaras, Leen Delrue, Bernard De Bruyne, William Wijns, Emanuele Barbato, Jozef Bartunek
Affiliations

Monocyte-platelets aggregates as cellular biomarker of endothelium-dependent coronary vasomotor dysfunction in patients with coronary artery disease

Luigi Di Serafino et al. J Cardiovasc Transl Res. 2014 Feb.

Abstract

Monocyte-platelet aggregates (MPA) are increased in patients with acute coronary syndrome. We investigated whether MPA are associated with the presence of functionally significant coronary stenoses or with coronary arterial endothelial dysfunction. One hundred forty five patients undergoing elective coronary angiography were prospectively enrolled. Functional significance of coronary stenosis was assessed by fractional flow reserve (FFR). Thirty randomly selected patients underwent pacing protocol to evaluate Coronary endothelium-dependent vasomotor function (CVF). Whole blood was drawn to evaluate MPA. In patients with FFR ≤ 0.8 (FFRpos, n = 75), MPA did not significantly differ from FFR >0.8 patients (FFRneg, n = 70) (38.1% [25.7-56.6] vs. 34.0% [20.5-49.9], p = 0.08). CVF was similar in FFRpos and FFRneg patients (percent vessel diameter change, %VDC = 7.19 % [6.01-10.9] vs. 8.0 % [0.81-9.80], p = 0.78). Yet, patients with abnormal CVF showed higher MPA as compared to patients with preserved CVF (28.3% [28.8-53.4] vs. 20.5 % [17.0-32.9], p = 0.01). Moreover, MPA was inversely correlated with %VDC (R2 = 0.26, p < 0.01). MPA levels are significantly higher in patients with abnormal coronary vasomotor function regardless of the presence of functionally significant coronary stenosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nat Med. 2002 Nov;8(11):1227-34 - PubMed
    1. J Am Coll Cardiol. 1998 Feb;31(2):352-8 - PubMed
    1. J Cardiovasc Transl Res. 2013 Jun;6(3):364-70 - PubMed
    1. N Engl J Med. 2007 Dec 13;357(24):2482-94 - PubMed
    1. Nature. 1998 Feb 5;391(6667):591-4 - PubMed

Publication types

MeSH terms

LinkOut - more resources