Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jan;15(1):7-21.
doi: 10.1038/nrg3606. Epub 2013 Dec 3.

Long non-coding RNAs: new players in cell differentiation and development

Alessandro Fatica  1 , Irene Bozzoni  2
Affiliations
Review

Long non-coding RNAs: new players in cell differentiation and development

Alessandro Fatica et al. Nat Rev Genet. 2014 Jan.

Abstract

Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nat Struct Mol Biol. 2013 May;20(5):566-73 - PubMed
    1. Genome Res. 2008 Sep;18(9):1433-45 - PubMed
    1. Development. 2008 Jan;135(2):227-35 - PubMed
    1. Cell Rep. 2013 Oct 17;5(1):3-12 - PubMed
    1. Science. 2008 Dec 12;322(5908):1717-20 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources