Polycystic Ovary Syndrome is the most common endocrine disorder in women of reproductive age, whose final pathogenesis remains unclear. PCOS is a distinctive disorder of follicular growth leading to obstruction of the selection of the dominant follicle, and as a result--arrest at small antral follicles. Anti-Mullerian hormone (AMH) is a glycoprotein produced in the granulosa cells of the ovary and having regard to the regulation of growth and development of follicles. Study of the relationship between AMH and PCOS are conflicting and few. It is believed that women with PCOS had significantly higher levels of AMH compared with healthy, which is associated with an increased number of antral follicles pre-or is the result of a specific offense of AMH synthesis by the granulosa cells causes follicular arrest in PCOS.

Objectives: Comparison of serum anti-Mullerian hormone (AMH) in women with polycystic ovary syndrome (PCOS) and healthy women (control group). As too study of correlation between serum Anti-Mullerian hormone (AMH) and other hormonal parameters.

Design: Prospective comparative study.

Material and methods: This study was conducted in the Department of Obstetrics and Gynecology at the Medical University of Plovdiv and the Department of Endocrinology at the Medical University of PIovdiv. We studied the 100 women aged between 18-35. Divided into two groups: 50 women with polycystic ovary syndrome (PCOS) selected according to the criteria of the American Society of Reproductive Medicine (ASRM)--Rotterdam in 2003 and control group of 50 healthy women. 15 women with PCOS and amenorrhea. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, androstenedione, estradiol (E2) and Anti-Mullerian hormone (AMH) were measured during the early follicular phase (3-5 days) of spontaneous menstrual cycle or progestin-induced uterine bleeding.

Results: There was a statistically significant difference in serum AMH when compared to the values in the two groups subject to the study. In group of women with PCOS are found positive correlation between serum levels of AMH and androstenedione, testosterone and luteinizing hormone and negative correlation between AMH, FSH and E2.

Conclusion: In this study group of women with PCOS had significantly higher serum levels of AMH compared with the control group. The presence of positive and negative correlations with other hormonal parameters revealed parts of AMH involvement in the pathogenesis of PCOS. These data on serum AMH levels in PCOS allow its use as a diagnostic criterion, but also the study of the level can serve as a reliable tool to characterize the severity of the syndrome, monitoring and forecasting.