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Editorial
. 2013 Dec;91(12):1329-31.
doi: 10.1007/s00109-013-1097-y.

The next generation of RAGE modulators: implications for soluble RAGE therapies in vascular inflammation

Marion A Hofmann Bowman  1 , Ann Marie Schmidt
Affiliations
Editorial

The next generation of RAGE modulators: implications for soluble RAGE therapies in vascular inflammation

Marion A Hofmann Bowman et al. J Mol Med (Berl). 2013 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Ligand-mediated activation of the Receptor for Advanced Glycation Endproducts (RAGE) mediates acute and sustained inflammation. Various ligands of RAGE, including Advanced Glycation Endproducts (AGEs), high mobility group protein box 1 (HMGB1), S100/calgranulins and lysophosphatidic acid (LPA) are released from various sources during cell stress and injury and bind to RAGE on endothelial cells, monocytes, and smooth muscle cells leading to activation of pathways resulting in translocation of transcription factor nuclear factor kappa B (NFkB) and increased oxidative stress, which in turn results in endothelial activation and pro-inflammatory cell phenotype.
Figure 2
Figure 2
Advanced remodeling with necrotic core, elastic fiber degradation, and calcification in atherosclerotic plaques of the innominate artery in apoE deficient mice with transgenic expression of hS100A12 targeted to the vascular smooth muscle and in wildtype apoE deficient littermate mice (modified from [6]).
See this image and copyright information in PMC

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References

    1. Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med. 1999;340:115–126. - PubMed
    1. Everett BM, Pradhan AD, Solomon DH, Paynter N, Macfadyen J, Zaharris E, Gupta M, Clearfield M, Libby P, Hasan AA, Glynn RJ, Ridker PM. Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis. Am Heart J. 2013;166:199–207. e115. - PMC - PubMed
    1. Yan SF, Ramasamy R, Schmidt AM. The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature. Circ Res. 2010;106:842–853. - PMC - PubMed
    1. Chan JK, Roth J, Oppenheim JJ, Tracey KJ, Vogl T, Feldmann M, Horwood N, Nanchahal J. Alarmins: awaiting a clinical response. J Clin Invest. 2012;122:2711–2719. - PMC - PubMed
    1. Das D, Gawdzik J, Dellefave-Castillo L, McNally EM, Husain A, Raman J, Hofmann Bowman MA. 9 S100A12 expression in thoracic aortic aneurysm is associated with increased risk of dissection and perioperative complications. J Am Coll Cardiol. 2012;60:775–785. - PMC - PubMed

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