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Review
. 2014 Apr;42(2):251-62.
doi: 10.1007/s15010-013-0546-4. Epub 2013 Nov 1.

Development of universal influenza vaccines based on influenza virus M and NP genes

M Zheng  1 , J Luo, Z Chen
Affiliations
Review

Development of universal influenza vaccines based on influenza virus M and NP genes

M Zheng et al. Infection. 2014 Apr.

Abstract

Purpose: Vaccination is the safest and most effective measure against influenza virus infections. However, traditional influenza vaccines cannot respond effectively to an unforeseen epidemic or pandemic caused by a virus with antigenic drifts or antigenic shifts. Therefore, developing a universal influenza vaccine (UIV) that induces broad-spectrum and long-term immunity has become a major trend in influenza vaccine research and development.

Methods: This article reviews the development of UIVs based on these conserved influenza virus proteins.

Results and conclusion: The matrix protein (M1, M2) and nucleoprotein (NP) of influenza viruses have highly conserved sequences, and they become the major target antigens of current UIV studies.

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