A "big data" view of the tumor "immunome"

doi:10.1016/j.immuni.2013.10.002

Comment

. 2013 Oct 17;39(4):631-2.

doi: 10.1016/j.immuni.2013.10.002.

A "big data" view of the tumor "immunome"

Nicholas P Restifo¹

Affiliations

Affiliation

¹ Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Center for Regenerative Medicine, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: restifo@nih.gov.

PMID: 24138879
PMCID: PMC3901363
DOI: 10.1016/j.immuni.2013.10.002

Comment

A "big data" view of the tumor "immunome"

Nicholas P Restifo. Immunity. 2013.

. 2013 Oct 17;39(4):631-2.

doi: 10.1016/j.immuni.2013.10.002.

Author

Nicholas P Restifo¹

Affiliation

¹ Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Center for Regenerative Medicine, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: restifo@nih.gov.

PMID: 24138879
PMCID: PMC3901363
DOI: 10.1016/j.immuni.2013.10.002

Abstract

Tumors are complex masses containing not just neoplastic cells but also stromal cells, neovasculature, and a gamut of immune cells. In this issue, Bindea et al. (2013) identify a surprising new "immune landscape" associated with prolonged disease-free survival.

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Figures

**Figure**
Immune cells in tumor. Tumors masses are complex mixtures of cells that contain stromal cells, vasculature and a wide array of immune cells. Unsupervised correlation matrix of intra-tumor ‘immunome’ reveals that of the 28 cell types that were specifically analyzed, the strongest correlations with increased disease-free survival were with CTL, Tfh and B cells (shown in bold), which furthermore were correlated with each other.

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Comment on

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.
Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, Bruneval P, Fridman WH, Becker C, Pagès F, Speicher MR, Trajanoski Z, Galon J. Bindea G, et al. Immunity. 2013 Oct 17;39(4):782-95. doi: 10.1016/j.immuni.2013.10.003. Immunity. 2013. PMID: 24138885

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References

1. Bindea Cite, et al. Immunity, Present Issue.
1. Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nature reviews. Cancer. 2012;12:298–306. - PubMed
1. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, Tosolini M, Camus M, Berger A, Wind P, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313:1960–1964. - PubMed
1. Hinrichs CS, Spolski R, Paulos CM, Gattinoni L, Kerstann KW, Palmer DC, Klebanoff CA, Rosenberg SA, Leonard WJ, Restifo NP. IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood. 2008;111:5326–5333. - PMC - PubMed
1. Khong HT, Restifo NP. Natural selection of tumor variants in the generation of "tumor escape" phenotypes. Nature immunology. 2002;3:999–1005. - PMC - PubMed

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[1] Bindea Cite, et al. Immunity, Present Issue.

[2] Bindea Cite, et al. Immunity, Present Issue.

[3] Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nature reviews. Cancer. 2012;12:298–306. - PubMed

[4] Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nature reviews. Cancer. 2012;12:298–306. - PubMed

[5] Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, Tosolini M, Camus M, Berger A, Wind P, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313:1960–1964. - PubMed

[6] Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, Tosolini M, Camus M, Berger A, Wind P, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313:1960–1964. - PubMed

[7] Hinrichs CS, Spolski R, Paulos CM, Gattinoni L, Kerstann KW, Palmer DC, Klebanoff CA, Rosenberg SA, Leonard WJ, Restifo NP. IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood. 2008;111:5326–5333. - PMC - PubMed

[8] Hinrichs CS, Spolski R, Paulos CM, Gattinoni L, Kerstann KW, Palmer DC, Klebanoff CA, Rosenberg SA, Leonard WJ, Restifo NP. IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood. 2008;111:5326–5333. - PMC - PubMed

[9] Khong HT, Restifo NP. Natural selection of tumor variants in the generation of "tumor escape" phenotypes. Nature immunology. 2002;3:999–1005. - PMC - PubMed

[10] Khong HT, Restifo NP. Natural selection of tumor variants in the generation of "tumor escape" phenotypes. Nature immunology. 2002;3:999–1005. - PMC - PubMed

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A "big data" view of the tumor "immunome"

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A "big data" view of the tumor "immunome"

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