The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

doi:10.1016/j.oraloncology.2013.09.008

Review

. 2014 Jun;50(6):565-74.

doi: 10.1016/j.oraloncology.2013.09.008. Epub 2013 Oct 14.

The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

Eleni Benson¹, Ryan Li², David Eisele³, Carole Fakhry⁴

Affiliations

¹ Johns Hopkins Medical Institutions, Department of Otolaryngology-Head and Neck Surgery., 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287, United States. Electronic address: ebenson6@jhmi.edu.
² Johns Hopkins Medical Institutions, Department of Otolaryngology-Head and Neck Surgery., 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287, United States. Electronic address: rli15@jhmi.edu.
³ Johns Hopkins Medical Institutions, Department of Otolaryngology-Head and Neck Surgery., 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287, United States. Electronic address: deisele1@jhmi.edu.
⁴ Johns Hopkins Medical Institutions, Department of Otolaryngology-Head and Neck Surgery., 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287, United States; Milton J. Dance Jr. Head and Neck Cancer Center, Baltimore, MD 21204, United States; Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 615 N Wolfe St., Baltimore, MD 21205, United States. Electronic address: cfakhry@jhmi.edu.

PMID: 24134947
PMCID: PMC4391706
DOI: 10.1016/j.oraloncology.2013.09.008

Review

The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

Eleni Benson et al. Oral Oncol. 2014 Jun.

. 2014 Jun;50(6):565-74.

doi: 10.1016/j.oraloncology.2013.09.008. Epub 2013 Oct 14.

Authors

Eleni Benson¹, Ryan Li², David Eisele³, Carole Fakhry⁴

Affiliations

¹ Johns Hopkins Medical Institutions, Department of Otolaryngology-Head and Neck Surgery., 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287, United States. Electronic address: ebenson6@jhmi.edu.
² Johns Hopkins Medical Institutions, Department of Otolaryngology-Head and Neck Surgery., 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287, United States. Electronic address: rli15@jhmi.edu.
³ Johns Hopkins Medical Institutions, Department of Otolaryngology-Head and Neck Surgery., 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287, United States. Electronic address: deisele1@jhmi.edu.
⁴ Johns Hopkins Medical Institutions, Department of Otolaryngology-Head and Neck Surgery., 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287, United States; Milton J. Dance Jr. Head and Neck Cancer Center, Baltimore, MD 21204, United States; Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 615 N Wolfe St., Baltimore, MD 21205, United States. Electronic address: cfakhry@jhmi.edu.

PMID: 24134947
PMCID: PMC4391706
DOI: 10.1016/j.oraloncology.2013.09.008

Abstract

Human papillomavirus (HPV) is etiologically responsible for a distinct subset of head and neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most commonly arise from the oropharynx and are responsible for the increasing incidence of oropharyngeal SCC (OSCC) in the United States (US) and abroad. HPV-positive OSCC (HPV-OSCC) has a unique demographic and risk factor profile and tumor biology. HPV-OSCC patients tend to be white, younger, and have a higher cumulative exposure to sexual behaviors as compared with HPV-negative OSCC patients. HPV-positive tumor status also significantly improves survival, and is indeed the single strongest prognostic factor for OSCC. The mechanisms that underlie the improved prognosis conferred by HPV-positive disease are unknown. The purpose of this review is to describe the clinical impact of HPV status in HNSCC, particularly in OSCC, both in terms of the unique clinic-demographic profile and prognostic implications.

Keywords: HPV; Head and neck cancer; Oropharyngeal neoplasms; Prognosis; Risk factors.

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Conflict of interest statement

None declared.

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References

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1. Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V, et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region. Head Neck. 2012 [Epub 2012/01/24]. doi: http://dx.doi.org/10.1002/hed.22015. - DOI - PubMed
1. Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29(32):4294–301. [Epub 2011/10/05]. doi: http://dx.doi.org/JCO.2011.36.4596[[pii] 10.1200/JCO.2011.36.4596. - PMC - PubMed
1. Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the US population ages 20–44 years. Cancer. 2005;103(9):1843–9. http://dx.doi.org/10.1002/cncr.20998. - DOI - PubMed
1. Colevas AD. Population-based evaluation of incidence trends in oropharyngeal cancer focusing on socioeconomic status, sex, and race/ethnicity. Head Neck. 2013 http://dx.doi.org/10.1002/hed.23253. - DOI - PubMed

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[1] Sikora AG, Toniolo P, DeLacure MD. The changing demographics of head and neck squamous cell carcinoma in the United States. Laryngoscope. 2004;114(11):1915–23. http://dx.doi.org/10.1097/01.mlg.0000147920.66486.bc. - DOI - PubMed

[2] Sikora AG, Toniolo P, DeLacure MD. The changing demographics of head and neck squamous cell carcinoma in the United States. Laryngoscope. 2004;114(11):1915–23. http://dx.doi.org/10.1097/01.mlg.0000147920.66486.bc. - DOI - PubMed

[3] Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V, et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region. Head Neck. 2012 [Epub 2012/01/24]. doi: http://dx.doi.org/10.1002/hed.22015. - DOI - PubMed

[4] Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V, et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region. Head Neck. 2012 [Epub 2012/01/24]. doi: http://dx.doi.org/10.1002/hed.22015. - DOI - PubMed

[5] Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29(32):4294–301. [Epub 2011/10/05]. doi: http://dx.doi.org/JCO.2011.36.4596[[pii] 10.1200/JCO.2011.36.4596. - PMC - PubMed

[6] Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29(32):4294–301. [Epub 2011/10/05]. doi: http://dx.doi.org/JCO.2011.36.4596[[pii] 10.1200/JCO.2011.36.4596. - PMC - PubMed

[7] Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the US population ages 20–44 years. Cancer. 2005;103(9):1843–9. http://dx.doi.org/10.1002/cncr.20998. - DOI - PubMed

[8] Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the US population ages 20–44 years. Cancer. 2005;103(9):1843–9. http://dx.doi.org/10.1002/cncr.20998. - DOI - PubMed

[9] Colevas AD. Population-based evaluation of incidence trends in oropharyngeal cancer focusing on socioeconomic status, sex, and race/ethnicity. Head Neck. 2013 http://dx.doi.org/10.1002/hed.23253. - DOI - PubMed

[10] Colevas AD. Population-based evaluation of incidence trends in oropharyngeal cancer focusing on socioeconomic status, sex, and race/ethnicity. Head Neck. 2013 http://dx.doi.org/10.1002/hed.23253. - DOI - PubMed

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The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

Affiliations

The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

Authors

Affiliations

Abstract

Conflict of interest statement

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References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials