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. 2014 Jun;37(3):149-52.
doi: 10.1016/j.clae.2013.09.008. Epub 2013 Oct 11.

Preparation, characterization and antimicrobial study of a hydrogel (soft contact lens) material impregnated with silver nanoparticles

Bibi Sedigheh Fazly Bazzaz  1 , Bahman Khameneh  2 , Mohammad-mehdi Jalili-Behabadi  3 , Bizhan Malaekeh-Nikouei  4 , Seyed Ahmad Mohajeri  5
Affiliations

Preparation, characterization and antimicrobial study of a hydrogel (soft contact lens) material impregnated with silver nanoparticles

Bibi Sedigheh Fazly Bazzaz et al. Cont Lens Anterior Eye. 2014 Jun.

Abstract

Purpose: Contact lenses that incorporate antimicrobial properties may reduce the risk for microbial-associated adverse events for lens wearers. The aim of this study was to assess the antimicrobial effects of silver nanoparticles (NP) when impregnated in a hydrogel material.

Methods: Hydrogel disks, used as a proxy for soft contact lenses, were prepared with silver NPs to add an antimicrobial effect to the polymer. Six groups of disks were created, each with a different concentration of silver NPs. The antimicrobial effect of the hydrogels against Pseudomonas aeruginosa (ATCC15442) and Staphylococcus aureus (ATCC6538) was evaluated at 6, 24, 48 and 72 h.

Results: Silver NP concentrations ranged from 20.71 to 98.06 μg/disk. All groups demonstrated excellent antibacterial effects against P. aeruginosa at each time point. After 6h all disks didn't exhibit desirable antibacterial activity against S. aureus; whereas except those with 20.71 μg silver NPs showed antibacterial activity at 24h and only the disks with 57.13 and 98.06 μg silver NPs showed antimicrobial activity at 48 and 72 h.

Conclusions: The development of contact lenses made of a silver NP-impregnated hydrogel material may bring antimicrobial effects sufficient to decrease the risk of microbial-related adverse events for lens wearers.

Keywords: Antimicrobial; Disinfection; Hydrogel; Keratitis; Microbial keratitis; Silver nanoparticles; Soft contact lens.

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