Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013;75(2-4):98-105.
doi: 10.1159/000353180. Epub 2013 Sep 27.

Genetic admixture and obesity: recent perspectives and future applications

José R Fernández  1 , Keith E Pearson, Kenneth P Kell, Michelle M Bohan Brown
Affiliations
Review

Genetic admixture and obesity: recent perspectives and future applications

José R Fernández et al. Hum Hered. 2013.

Abstract

The process of the colonization of the New World that occurred centuries ago served as a natural experiment, creating unique combinations of genetic material in newly formed admixed populations. Through a genetic admixture approach, the identification and genotyping of ancestry informative markers have allowed for the estimation of proportions of ancestral parental populations among individuals in a sample. These admixture estimates have been used in different ways to understand the genetic contributions to individual variation in obesity and body composition parameters, particularly among diverse admixed groups known to differ in obesity prevalence within the United States. Although progress has been made through the use of genetic admixture approaches, further investigations are needed in order to explore the interaction of environmental factors with the degree of genetic ancestry in individuals. A challenge to confront at this time would be to further stratify and define environments in progressively more granular terms, including nutrients, muscle biology, stress responses at the cellular level, and the social and built environments.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Association of BMI and the interaction of PUFA intake and Amerindian admixture in a multiethnic sample of children. Predicted BMI calculated from multiple variable linear regression model including Amerindian admixture, PUFA intake, interaction of Amerindian admixture and PUFA intake controlled for age, sex, ethnicity, tanner stage, total energy intake, and socioeconomic status. PUFA intake and Amerindian admixture interaction was significant (p = 0.0471). Symbols represent the following levels of Amerindian admixture formula image (0%), formula image (25%), formula image (50%), formula image (75%) and + (100%).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Schwartz AG, Wenzlaff AS, Bock CH, Ruterbusch JJ, Chen W, Cote ML, Artis AS, Van Dyke AL, Land SJ, Harris CC, Pine SR, Spitz MR, Amos CI, Levin AM, McKeigue PM. Admixture mapping of lung cancer in 1812 African-Americans. Carcinogenesis. 2011;32:312–317. - PMC - PubMed
    1. Fejerman L, Chen GK, Eng C, Huntsman S, Hu D, Williams A, Pasaniuc B, John EM, Via M, Gignoux C, Ingles S, Monroe KR, Kolonel LN, Torres-Mejia G, Perez-Stable EJ, Burchard EG, Henderson BE, Haiman CA, Ziv E. Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US Latinas. Hum Mol Genet. 2012;21:1907–1917. - PMC - PubMed
    1. Ricks-Santi LJ, Apprey V, Mason T, Wilson B, Abbas M, Hernandez W, Hooker S, Doura M, Bonney G, Dunston G, Kittles R, Ahaghotu C. Identification of genetic risk associated with prostate cancer using ancestry informative markers. Prostate Cancer Prostatic Dis. 2012;15:359–364. - PMC - PubMed
    1. Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni A, Herrington D, Wagenknecht LE, Langefeld CD, Freedman BI. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes. Circ Cardiovasc Genet. 2012;6:97–105. - PMC - PubMed
    1. Allison MA, Peralta CA, Wassel CL, Aboyans V, Arnett DK, Cushman M, Eng J, Ix J, Rich SS, Criqui MH. Genetic ancestry and lower extremity peripheral artery disease in the Multi-Ethnic Study of Atherosclerosis. Vasc Med. 2010;15:351–359. - PMC - PubMed

Publication types

Substances