Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Apr;36(3):e202-6.
doi: 10.1097/MPH.0000000000000037.

Ectopic production of β-hCG by osteosarcoma: a case report and review of the literature

Benjamin R Oshrine  1 , Lisa M Sullivan, Naomi J Balamuth
Affiliations
Review

Ectopic production of β-hCG by osteosarcoma: a case report and review of the literature

Benjamin R Oshrine et al. J Pediatr Hematol Oncol. 2014 Apr.

Abstract

Ectopic production of β-human chorionic gonadotropin (β-hCG) by nontrophoblastic tumors has been reported but mostly in carcinomas. We report a case of an adolescent female patient with a epithelioid osteosarcoma that was discovered to secrete β-hCG after routine pregnancy testing. Immunohistochemical staining of her primary tumor biopsy demonstrated immunoreactivity for β-hCG. Levels of serum β-hCG were monitored throughout her therapy and demonstrated normalization with effective systemic therapy and local control. She remains disease free 6 months off therapy, with undetectable hormone levels. A review of the available literature on β-hCG production by sarcomas is also presented.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

Substances

LinkOut - more resources