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Review
. 2013 Dec;25(12):2805-11.
doi: 10.1016/j.cellsig.2013.09.006. Epub 2013 Sep 13.

Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway

Xu Sun  1 , Yong He, Cheng Huang, Tao-Tao Ma, Jun Li
Affiliations
Review

Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway

Xu Sun et al. Cell Signal. 2013 Dec.

Abstract

As the crucial biological regulators, microRNAs that act by suppressing their target genes are involved in a variety of pathophysiological processes. It is generally accepted that microRNAs are often dysregulated in many types of neoplasm and other human diseases. In neoplasm, microRNAs may function as oncogenes or tumor suppressors. As constitutive activation of the Wnt signaling pathway is a common feature of neoplasm and contributes to its development, progression and metastasis in various cancers, numerous studies have revealed that microRNA-mediated gene regulation are interconnected with the Wnt/β-catenin signaling pathway, forming a Wnt/β-catenin-microRNA regulatory network, which is critical to successful targeting of the Wnt/β-catenin pathway for oncotherapy. In this review, we aim to accumulate recent advances on microRNAs that work in tandem with Wnt/β-catenin signaling in tumorigenesis, with particular focus on how microRNAs affect Wnt/β-catenin activity as well as how microRNAs are regulated through the Wnt/β-catenin pathway.

Keywords: APC; Adenomatous polyposis coli; CK1α; Casein kinase 1α; DKK; Dickkop; Disheveled; Dvl; EZH2; FZD; Frizzled; GSK3β; Glycogen synthase kinase 3β; HCC; Hepatocellular carcinoma; IRS; Insulin receptor substrate; LDL receptor–related protein; LEF; LRP; Lymphoid enhancer-binding factor; NLK; Nemo-like kinase; Neoplasm; Secreted frizzled-related proteins; T-cell factor; TCF; WIF; Wnt inhibitory factor; Wnt/β-catenin signaling; Wnt–microRNA regulatory network; Zeste homologue 2; miRs; microRNA; microRNAs; sFRPs.

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