Review
[Distribution and regulation of Panx1 protein]
[Article in
Chinese]
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- PMID: 24027825
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Review
[Distribution and regulation of Panx1 protein]
[Article in
Chinese]
Sheng Li Ke Xue Jin Zhan.
2013 Jun.
Abstract
Pannexin1 (Panx1) is a subtype of the newly discovered gap junction proteins named Pannexin(s). Panx1 is widely expressed in the nervous system, cardiovascular system, etc and can form non-selective and large conductance hemichannel. It has been demonstrated that various conditions can regulate Panx1 open and affect the body's physiological function via macromolecular substance (for instance, ATP) releasing. This review gives a detailed introduction to the main distribution of Panxl, summarizes the open and inhibition condition of Panx1, and finally, prospects directions of future research.
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